MC1568|852475-26-4|-陌孚医药/Medlife

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MC1568

目录号: PL04677 纯度: ≥97%

CAS No. :852475-26-4

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中文名称	MC1568
中文别名	3-[4-[3-(3-氟苯基)-3-氧代-1-丙烯基]-1-甲基-1H-吡咯-2-基]-N-羟基-2-丙烯酰胺;MC1568 抑制剂
英文名称	MC1568
英文别名	MC1568;(E)-3-[4-[(E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl]-1-methylpyrrol-2-yl]-N-hydroxyprop-2-enamide;MC-1568;MC1568 (MC-1568, MC 1568);(E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide;MC-1568,MC1568;3-[5-(3-(3-Fluorophenyl)-3-oxopropen-1-yl)-1-methyl-1H-pyrrol-2-yl]-N-hydroxy-2-propenamide;HDAC-IN-1;MC 1568;3-(4-(3-(3-fluorophenyl)-3-oxoprop-1-enyl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide;(E)-3-(4-((E)-3-(3-fluorophenyl)-3-oxoprop-1-en-1-yl)-1-methyl-1H-pyrrol-2-yl)-N-hydroxyacrylamide;MLS006011094
Cas No.	852475-26-4
分子式	C₁₇H₁₅FN₂O₃
分子量	314.31
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	MC1568是组蛋白脱乙酰酶(HDAC II)的抑制剂，可用于癌症研究。
生物活性	MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor, used for cancer research.
性状	Solid
IC50 & Target[1][2]	HDAC
体外研究(In Vitro)	MC1568 arrests myogenesis by decreasing myocyte enhancer factor 2D (MEF2D) expression, by stabilizing the HDAC4–HDAC3–MEF2D complex, and paradoxically, by inhibiting differentiation-induced MEF2D acetylation. MC1568 and MC1575 inhibits IL-8 levels and cell proliferation in either unstimulated or PMA-stimulated melanoma cells. They acts by suppressing c-Jun binding to the IL-8 promoter, recruitment of histones 3 and 4, RNA polymerase II and TFIIB to the c-Jun promoter, and c-Jun expression. MC1568 interferes with the RAR- and PPARγ-mediated differentiation-inducing signaling pathways. In F9 cells, this inhibitor specifically blocks endodermal differentiation. In 3T3-L1 cells, MC1568 attenuates PPARγ-induced adipogenesis. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	MC1568 shows an apparent tissue-selective HDAC inhibition. In skeletal muscle and heart, MC1568 inhibits the activity of HDAC4 and HDAC5 without affecting HDAC3 activity, thereby leaving MEF2–HDAC complexes in a repressed state. MC1568 increases mortality and lesion volume and did not improve functional outcome. In addition, MC1568 decreases microtubule associated protein 2, phosphorylated neurofilament heavy chain and myelin basic protein immunoreactivity in the periinfarct cortex. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Nebbioso A, et al. Selective class II HDAC inhibitors impair myogenesis by modulating the stability and activity ofHDAC-MEF2 complexes. EMBO Rep. 2009 Jul;10(7):776-82. [2]. Venza I, et al. Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells. Pigment Cell Melanoma Res. 2013 Mar;26(2):193-204.

溶解度数据	In Vitro: DMSO : 18.5 mg/mL (58.86 mM; Need ultrasonic and warming)配制储备液

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