EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) 是一种有效的细胞氧化应激保护剂，抑制细胞发生铁死亡 (ferroptosis)，可用于线粒体疾病的研究。EPI-743 是维生素 E 类似物，具有口服活性，可以通过影响细胞内谷胱甘肽的氧化还原状态来防止过量的 ROS 产生。

EPI-743 (Vatiquinone; α-Tocotrienol quinone; PTC-743; NCT04378075) is a potent cellular oxidative stress protectant, inhibits ferroptosis in cells, which could be used for the study for mitochondrial diseases. EPI-743 is a synthetic analog of vitamin E with oral activity, targets repletion of reduced intracellular glutathione.

Liquid

Mitochondria.

Ferroptosis is a form of iron- and lipid-dependent regulated cell death associated with glutathione depletion and production of lipid peroxides by lipoxygenase enzymes.
EPI-743 prevents RSL3-induced ferroptosis in PCH6 patient fibroblasts with mean EC50 potency values of 17.3-21.8 nM.
EPI-743 (37, 111, 333 nM; 24 h) exhibits prevention of BODIPY 581/591 C11 lipid oxidation.
EPI-743 (0.1 nM-1 mM; 48 h) potently prevents ferroptosis induced by RSL3 (2 μM), FeC (100 μM), BSO (50 μM).
EPI-743 (1 μM, 3 h) is reduced to EPI-743 hydroquinone (EPI-743-HQ) in PCH6 patient fibroblasts, and EPI-743-HQ (0.1-100 μM; 30 min) inhibits human 15-LO enzyme activity with 20% inhibition at 100 μM, and IC50 is 4.4 μM.
has not independently confirmed the accuracy of these methods. They are for re

Room temperature in continental US; may vary elsewhere.

Pure form -20°C 3 years；In solvent -80°C 6 months

[1]. Kouga T, et al. Japanese Leigh syndrome case treated with EPI-743. Brain Dev. 2018 Feb;40(2):145-149. Brain Dev. 2018 Feb;40(2):145-149.
[2]. Avula S, et al. Treatment of Mitochondrial Disorders. Curr Treat Options Neurol. 2014. 16:292.
[3]. Kahn-Kirby AH, et al. Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial dise

In Vitro: DMSO : 100 mg/mL (226.93 mM; Need ultrasonic)配制储备液