Maribavir|176161-24-3|(马立巴韦; 1263W94; BW1263W94; GW257406X)-陌孚医药/Medlife

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Maribavir (Synonyms: 马立巴韦; 1263W94; BW1263W94; GW257406X)

目录号: PL04609 纯度: ≥99%

CAS No. :176161-24-3

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中文名称	Maribavir
中文别名	(2S,3s,4r,5s)-2-(5,6-二氯-2-(异丙基氨基)-1H-苯并[d]咪唑-1-基)-5-(羟基甲基)四氢呋喃-3,4-二醇;BENZIMIDAVIR 苯并咪唑核苷;马立巴韦;苯并咪唑核苷
英文名称	Maribavir
英文别名	(2S,3S,4R,5S)-2-(5,6-Dichloro-2-(isopropylamino)-1H-benzo[d]imidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol;(2S,3S,4R,5S)-2-(5,6-Dichloro-2-(isopropylamino)-1H-benzo[d]-imidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol;(2S,3S,4R,5S)-2-[5,6-dichloro-2-(propan-2-ylamino)benzimidazol-1-yl]-5-(hydroxymethyl)oxolane-3,4-diol;1H-Benzimidazol-2-amine, 5,6-dichloro-N-(1-methylethyl)-1-β-L-ribofuranosyl-;1H-Benzimidazol-2-amine,5,6-dichloro-N-(1-methylethyl)-1-b-L-ribofuranosyl-;BENZIMIDAVIR;1263W94;BW1263W94;Bzurea;Camvia;Camvia (TN);Camvia(TM);GW257406X;Maribavir;5,6-Dichloro-N-(1-methylethyl)-1-beta-L-ribofuranosyl-1H-benzimidazol-2-amine;5,6-DICHLORO-2-ISOPROPYLAMINO-1-(-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE;5,6-DICHLORO-2-(ISOPROPYLAMINO)-1-(BETA-L-RIBOFURANOSYL)-1H-BENZIMIDAZOLE;BENZIMIDAVIR, 5,6-DICHLORO-2-（ISOPROPYLAMINO）-1-(β-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE;BENZIMIDAVIR: 5,6-DICHLORO-2-(ISOPROPYLAMINO)-1-(SS-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE;BW 1263W94;GW 257406X
Cas No.	176161-24-3
分子式	C₁₅H₁₉N₃O₄Cl₂
分子量	376.24
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Maribavir 是一种有效抑制野生型 pUL97 催化的组蛋白磷酸化，IC₅₀ 为 3 nM。Maribavir 可有效作用于 HCMV 和 Epstein-Barr 病毒 (EBV)。

生物活性

Maribavir is a potent inhibitor of histone phosphorylation catalyzed by wild-type pUL97 in vitro, with an IC 50 of 3 nM. Maribavir has potent antiviral activity against HCMV and Epstein-Barr virus (EBV).

性状

Solid

IC50 & Target[1][2]

HCMV

体外研究(In Vitro)

Maribavir is a potent inhibitor of the autophosporylation of the wild type and all the major Ganciclovir (GCV) resistant UL97 mutants analysed with a mean IC50 of 35 nM. The M460I mutation results in hypersensitivity to Maribavir with an IC50 of 4.8 nM. A Maribavir resistant mutant of UL97 (L397R) is functionally compromised as both a Ganciclovir kinase and a protein kinase (~ 10% of wild type levels). Enzyme kinetic experiments demonstrate that Maribavir is a competitive inhibitor of ATP with a Ki of 10 nM. Maribavir (1263W94) inhibits viral replication in a dose-dependent manner, with IC50 of 0.12±0.01 μM as measured by a multicycle DNA hybridization assay. The pUL97 protein kinase is strongly inhibited by Maribavir, with 50% inhibition occurring at 3 nM. has not independent

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Shannon-Lowe CD, et al. The effects of Maribavir on the autophosphorylation of ganciclovir resistant mutants of the cytomegalovirus UL97 protein. Herpesviridae. 2010 Dec 7;1(1):4.
[2]. Biron KK, et al. Potent and selective inhibition of human cytomegalovirus replication by 1263W94, a benzimidazole L-riboside with a unique mode of action. Antimicrob Agents Chemother. 2002 Aug;46(8):2365-72.

溶解度数据	In Vitro: DMSO : 200 mg/mL (531.58 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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