AZ20|1233339-22-4|-陌孚医药/Medlife

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AZ20

目录号: PL04455 纯度: ≥99%

CAS No. :1233339-22-4

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中文名称	AZ20
中文别名	AZ20 抑制剂;4-[4-[(3R)-3-甲基-4-吗啉基]-6-[1-(甲基磺酰基)环丙基]-2-嘧啶基]-1H-吲哚
英文名称	AZ20
英文别名	AZ 20;(3R)-4-[2-(3H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine;AZ-20;4{4-[(3R)3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}1Hindole;AZ20;(3R)-4-[2-(1H-indol-4-yl)-6-(1-methylsulfonylcyclopropyl)pyrimidin-4-yl]-3-methylmorpholine;4-[4-(1-methanesulfonylcyclopropyl)-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-2-yl]-1H-indole;compound 6 [PMID: 46244454];GTPL8477;SYN5157;AOB6937;SCGCBAAYLFTIJU-CQSZACIVSA-N;BDBM50427326;s7050;SB19279;AZ20, >=98% (HPLC);BC600472;Y1867;SW219703-1;4-
Cas No.	1233339-22-4
分子式	C₂₁H₂₄N₄O₃S
分子量	412.51
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	AZ20 是一种有效的，选择性的 ATR 抑制剂，IC₅₀ 值为 5 nM；同时可抑制 mTOR 活性，IC₅₀ 值为 38 nM。
生物活性	AZ20 is a potent and selective inhibitor of ATR with an IC 50 of 5 nM, and has 8-fold selectivity against mTOR (IC 50 =38 nM).
性状	Solid
IC50 & Target[1][2]	ATR 5 nM (IC50) mTOR 38 nM (IC50
体外研究(In Vitro)	AZ20 inhibits ATR immunoprecipitated from HeLa nuclear extracts with an IC50 of 5 nM and ATR mediated phosphorylation of Chk1 in HT29 colorectal adenocarcinoma tumor cells with an IC50 of 50 nM. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	AZ20 (25, 50 mg/kg, p.o.) has high permeability combined with good stability to rat hepatocytes and, despite the lack of progress in achieving markedly higher solubility, has respectable bioavailability in a low dose rat PK study. AZ20 (25, 50 mg/kg, p.o.) leads to significant tumor growth inhibition in female nude mice bearing LoVo tumors. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Foote KM, et al. Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity. J Med Chem. 2013 Mar 14

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (242.42 mM)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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