(S)-Gossypol (acetic acid)|1189561-66-7|((S)-(+)-Gossypol acetic acid)-陌孚医药/Medlife

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(S)-Gossypol (acetic acid) (Synonyms: (S)-(+)-Gossypol acetic acid)

目录号: PL04438 纯度: ≥99%

CAS No. :1189561-66-7

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中文名称	(S)-Gossypol (acetic acid)
中文别名	(S)-Gossypol (acetic acid)
英文名称	(S)-Gossypol (acetic acid)
英文别名	(S)-Gossypol (acetic acid);(S)-(+)-Gossypol acetic acid;gossypol-Acetic acid;Gossypol acetate;Acetate gossypol;(-)-Gossypol acetic acid;Gossypol (acetic acid);AT101;GOSSYPOL-ACETIC ACID COMPLEX;Gossypol AcOH Salt;MLS002702979;MLS000028630;NSC19048;SMR000058743;(S)-Gossypol acetic acid;(R)-Gossypol acetic acid;Gossypol acetate, (R)-;Gossypol acetic acid, R-;R-(-)-gossypol acetic acid;Gossypol acetic acid, (R)-;Acet
Cas No.	1189561-66-7
分子式	C₃₂H₃₄O₁₀
分子量	578.61
包装储存	-20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

产品详情	(S)-Gossypol acetic acid 是天然产物 Gossypol 的异构体。(S)-Gossypol 以高亲和力结合到 Bcl-xL 和 Bcl-2 蛋白的 BH3 结合沟。
生物活性	(S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of Bcl-xL and Bcl-2 proteins with high affinity.
性状	Solid
IC50 & Target[1][2]	Bcl-2 Bcl-xL
体外研究(In Vitro)	The natural racemic Gossypol has two enantiomers, namely the (-)-Gossypol and (S)-Gossypol ((+)-Gossypol) enantiomers. (+)-Gossypol and (-)-Gossypol binds to Bcl-2 or Bcl-xL with similar binding affinities. (-)-Gossypol is more potent than (+)-Gossypol in inhibition of cell growth and induction of apoptosis. The racemic form and each of the enantiomers of Gossypol are tested against UM-SCC-6 and UM-SCC-14A in 6-day MTT assays. (-)-Gossypol exhibits greater growth inhibition relative to (±)-Gossypol than (+)-Gossypol in both cell lines tested (P<0.001). An intermediate growth inhibitory effect is observed with (±)-Gossypol but this effect is only observed at the higher dose of Gossypol (10 μM, P<0.0001). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
参考文献	[1]. Oliver CL, et al. In vitro effects of the BH3 mimetic, (-)-Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10(22):7757-63.

溶解度数据	In Vitro: DMSO : 50 mg/mL (86.41 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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