c-Kit-IN-1
目录号: PL04391 纯度: ≥98%
CAS No. :1225278-16-9
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中文名称
c-Kit-IN-1
中文别名
DCC-2618 抑制剂;N-[2,5-二氟-4-[[2-(1-甲基-1H-吡唑-4-基)-4-吡啶基]氧基]苯基]-N'-苯基-1,1-环丙烷二甲酰胺
英文名称
c-Kit-IN-1
英文别名
DCC-2618;N-(2,5-Difluoro-4-{[2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy} phenyl)-N'-phenyl-1,1-cyclopropanedicarboxamide;2-(4-Butoxyphenoxy)-N-(2,5-diethoxyphenyl)-N-(2-diethylaminoethyl)acetamide;DCC 2618;Fenoxedil;Fenoxedil (unspecified);Fenoxedilum;Fenoxedilum [INN-Latin];N-(2,5-Diethoxyphenyl)-N-(2-diethylaminoethyl)-4-butoxyphenoxy-acetamid;N-(2,5-difluoro-4-(2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yloxy)phenyl)-N'-phenylcyclopropane-1,1-dicarboxamide;Suplexedil;N-[2,5-Difluoro-4-[[2-(1-methyl-1H-pyrazol-4-yl)-4-pyridinyl]oxy]phenyl]-N'-phenyl-1,1-cyclopropanedicarboxamide;c-Kit-IN-1;pdgfr-inhibitor-1;PDGFR inhibitor 1;WWOXKWLDMLMYQY-UHFFFAOYSA-N;BCP05207;DCC 2618;DCC2618;BCP9000592;BC600530;AK547117;N'1-(2,5-difluoro-4-{[2-(1-methyl-1H-pyrazol-4-yl)pyridin-4-yl]oxy}phenyl)-N1-phenylcyclopropane-1,1-dicarboxamide;1-N'-[2,5-difluoro-4-[2-(1-methylpyrazol-4-yl)pyridi
Cas No.
1225278-16-9
分子式
C26H21F2N5O3
分子量
489.47
包装储存
Powder -20°C 3 years;4°C 2 years
产品详情
c-Kit-IN-1 是一种有效的 c-Kit 和 c-Met 抑制剂,IC50 值 <200 nM。
生物活性
c-Kit-IN-1 is a potent inhibitor of c-Kit and c-Met with IC 50 s of <200 nM.
性状
Solid
IC50 & Target[1][2]
IC50: <200 nM (c-Met), <200 nM (c-Kit), <2 μM (KDR), <10 μM (PDGFRα), <10 μM (PDGFRβ)
体外研究(In Vitro)
c-Kit-IN-1 is a c-Kit and c-Met inhibitor extracted from patent 2010051373A1, compound example 45, has an IC50 of <200 nM. c-Kit-IN-1 also inhibits KDR, PDGFR α and β with IC50s of <2 μM, <10 μM and <10 μM, respectively. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
参考文献
[1]. Daniel L. Flynn, et al. Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities. WO 2010051373 A1
溶解度数据
In Vitro: DMSO : ≥ 100 mg/mL (204.30 mM)配制储备液
搜索质检报告(COA)

1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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