Antiviral agent 24 is a potent antiviral agent with EC 50 values of 0.101, 19.9, 91.2 μM for EV71, CVA21, EV68, respectively. Antiviral agent 24 inhibits METTL3/METTL14 activity in a dose-dependent manner.
性状
Solid
体外研究(In Vitro)
Antiviral agent 24 (compound 25) (0-1000 μM) 抑制 METTL3/METTL14 复合物活性,EC50 值为 129 μM。 has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;In solvent -80°C 6 months
参考文献
[1]. Salerno M, et al. Rational design of novel nucleoside analogues reveals potent antiviral agents for EV71. Eur J Med Chem. 2022 Nov 24;246:114942.
溶解度数据
In Vitro: DMSO : 250 mg/mL (587.74 mM; Need ultrasonic)配制储备液