DC-U4106|2410534-62-0|-陌孚医药/Medlife

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DC-U4106

目录号: PL04335 纯度: ≥99%

CAS No. :2410534-62-0

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PL04335-50mg	50mg	询价	询价
PL04335-100mg	100mg	询价	询价

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中文名称	DC-U4106
英文名称	DC-U4106
英文别名	4H-1-Benzopyran-4-one, 8-[(3,5-dimethyl-1H-pyrazol-4-yl)oxy]-5,7-dihydroxy-2-[4-[4-(2-pyridinyl)-1-piperazinyl]phenyl]-;DC-U4106
Cas No.	2410534-62-0
分子式	C₂₉H₂₇N₅O₅
分子量	525.56
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情	DC-U4106 是一种 USP8 靶向抑制剂，其 K_d 值为 4.7 μM，IC₅₀ 值为 1.2 μM。DC-U4106 可作用于泛素化途径，促进 Erα 的降解。DC-U4106 可以抑制剂肿瘤细胞的生长，具有较小毒性，可用于乳腺癌研究。
生物活性	DC-U4106 is a USP8 targeting inhibitor with the K d value of 4.7 μM and the IC 50 value of 1.2 μM. DC-U4106 can target the ubiquitin pathway and facilitate the degradation of Erα. DC-U4106 inhibits tumor growth with minimal toxicity and has the potential for the research of breast cancer.
性状	Solid
IC50 & Target[1][2]	Kd: 4.7 μM (USP8), IC50: 1.2 μM (USP8).
体外研究(In Vitro)	DC-U4106 (1.2-45.2 μM) inhibits USP8 and USP2 with the IC50 values of 1.2 μM and 58.4 μM, respectively, and no activity in USP7. DC-U4106 (0-7 μM, 24 hours) reduces mRNA levels of ERα and PR. DC-U4106 (0-5 μM, 24 hours) can regulate the RTK pathway related proteins and the expression of ERα and PR proteins. DC-U4106 (0-5 μM, 12 hours) can induce apoptosis and inhibit cell proliferation. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	DC-U4106 (intraperitoneal injection, 5 mg/kg or 20 mg/kg, every 2 days, 14 days) inhibits the proliferation of tumors and no significantly effects on body weight, organ morphology and structure in BALB/c nude mice. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Yucheng Tian, et al. Discovery of Potent Small-Molecule USP8 Inhibitors for the Treatment of Breast Cancer through Regulating ERα Expression. J Med Chem. 2022 Jul 5.

溶解度数据	In Vitro: THF : 10 mg/mL (19.03 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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