(S)-Mapracorat|887375-15-7|((S)-ZK-245186; (S)-BOL-303242X)-陌孚医药/Medlife

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(S)-Mapracorat (Synonyms: (S)-ZK-245186; (S)-BOL-303242X)

目录号: PL04284 纯度: ≥99%

CAS No. :887375-15-7

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中文名称	(S)-Mapracorat
英文名称	(S)-Mapracorat
英文别名	(S)-Mapracorat;(2S)-1,1,1-trifluoro-4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)-4-methyl-2-[[(2-methylquinolin-5-yl)amino]methyl]pentan-2-ol;(S)-ZK-245186;(S)-BOL-303242X
Cas No.	887375-15-7
分子式	C₂₅H₂₆F₄N₂O₂
分子量	462.48
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	(S)-Mapracorat 是一种选择性且活性较小的糖皮质激素受体激动剂。
生物活性	(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.
性状	Solid
体外研究(In Vitro)	(S)-Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with (S)-Mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. B?umer W , et al. The selective glucocorticoid receptor agonist mapracorat displays a favourable safety-efficacy ratio for the topical treatment of inflammatory skin diseases in dogs. Vet Dermatol. 2017 Feb; 28(1):46-e11.

溶解度数据	In Vitro: DMSO : ≥ 50.6 mg/mL (109.41 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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