Aldometanib||(LXY-05-029)-陌孚医药/Medlife

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Aldometanib (Synonyms: LXY-05-029)

目录号: PL04256 纯度: ≥99%

商品编号	规格	价格	会员价
PL04256-5mg	5mg	¥1112.73	请登录
PL04256-10mg	10mg	¥1780.36	请登录
PL04256-25mg	25mg	¥3400.00	请登录
PL04256-50mg	50mg	¥5378.18	请登录
PL04256-100mg	100mg	¥8654.55	请登录
PL04256-200mg	200mg	询价	询价
PL04256-500mg	500mg	询价	询价

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中文名称	Aldometanib
英文名称	Aldometanib
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Aldometanib (LXY-05-029) 是一种醛缩酶抑制剂。Aldometanib 可以激活溶酶体腺苷-磷酸活化蛋白激酶 AMPK 并降低血糖。Aldometanib 可用于代谢稳态的研究。
生物活性	Aldometanib (LXY-05-029) is an orally active aldolase inhibitor. Aldometanib can activate lysosomal adenosine monophosphate-activated protein kinase (AMPK) and decreases blood glucose. Aldometanib can be used for the research of metabolic homeostasis.
性状	Solid
体外研究(In Vitro)	Aldometanib (0-1000 nM; 2 h) activates AMPK by preventing aldolase from binding to FBP to engender a pseudo-starvation signal. has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis
体内研究(In Vivo)	Aldometanib (oral; 0-10 mpk) reduces blood glucose in lean mice. Aldometanib (oral; 2-10 mpk; twice daily; for a week) reduces blood glucose and alleviates fatty liver in obese hyperglycaemic mice. Aldometanib alleviates fatty liver and nonalcoholic steatohepatitis. Aldometanib (oral; 2mpk; twice-daily; for a month) alleviates liver fibrosis in NASH mice. Aldometanib (oral; 0-50 μM; 0-50 days) extends lifespan in C. elegans via the lysosomal pathway. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Chen-Song Zhang, et al. The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK. Nat Metab. 2022 Oct 10.

溶解度数据	In Vitro: DMSO : 100 mg/mL (168.51 mM; ultrasonic and warming and heat to 60°C)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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