DRB18||-陌孚医药/Medlife

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DRB18

目录号: PL04140 纯度: ≥98%

商品编号	规格	价格	会员价
PL04140-5mg	5mg	¥3585.45	请登录
PL04140-10mg	10mg	¥5687.27	请登录
PL04140-25mg	25mg	¥11374.55	请登录
PL04140-50mg	50mg	¥18298.18	请登录
PL04140-100mg	100mg	询价	询价
PL04140-200mg	200mg	询价	询价
PL04140-10mM*1mLinDMSO	10mM*1mLinDMSO	¥3944.00	请登录

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中文名称	DRB18
英文名称	DRB18
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	DRB18 是一种有效的葡萄糖转运蛋白 (GLUT) 泛抑制剂。DRB18 通过改变葡萄糖相关途径中代谢产物的丰度来改变 A549 细胞中的能量相关代谢。DRB18 最终可导致细胞阻滞在 G1/S 期，增加氧化应激和坏死细胞死亡。DRB18 具有抗肿瘤活性。
生物活性	DRB18 is a potent pan-class GLUT inhibitor. DRB18 alters energy-related metabolism in A549 cells by changing the abundance of metabolites in glucose-related pathways. DRB18 can eventually lead to G1/S phase arrest and increase oxidative stress and necrotic cell death. DRB18 has anti-tumor activity.
性状	Solid
IC50 & Target[1][2]	GLUT
体外研究(In Vitro)	DRB18 (0-10 μM; 30 min) reduces glucose uptake in GLUT1-4-expressed HEK293 cell lines in a dose-dependent manner with IC50s varying from ~ 900 nM to ~ 9 μM. DRB18 (5 and 10 μM; 72 hours) causes cell cycle arrest in the G1/S phase transition. DRB18 (5 and 10 μM; 72 hours) increases ROS levels in A549 cells. DRB18 (5 and 10 μM; 72 hours) reduces expression of glycosylated GLUT1 and GLUT2-4 in A549 cells in a dose-dependent manner. has not independently confirmed the accuracy of these methods. They are for reference only. DRB18 (10 mg/kg; IP; thrice a week for 5 weeks) inhibits tumors volume by 44% and tumors weight by 43%. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male NU/J nude mice (3-4 weeks;
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Shriwas P, Roberts D, Li Y, et al. A small-molecule pan-class I glucose transporter inhibitor reduces cancer cell proliferation in vitro and tumor growth in vivo by targeting glucose-based metabolism. Cancer Metab. 2021;9(1):14. Published 2021 Mar 26.

溶解度数据	In Vitro: DMSO : 50 mg/mL (130.59 mM; ultrasonic and warming and heat to 60°C)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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