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产品总数：60957
O)N)%3dO)
| 中文名称 |
L-Glutamic acid-1-13C
|
|---|---|
| 中文别名 |
L-谷氨酸-2-13C;L-谷氨酸-1-13C
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| 英文名称 |
L-Glutamic acid-1-13C
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| 英文别名 |
L-<1-13C>glutamic acid;(S)-2-Aminopentanedioic acid-1-13C;13C Labeled L-glutamic acid;Glu-1-13C;L-Glutamic acid-2-13C;L-GLUTAMIC ACID (1-13C)
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| Cas No. |
81201-99-2
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| 分子式 |
C5H9NO4
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| 分子量 |
148.12
|
| 包装储存 |
4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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| 产品详情 |
L-Glutamic acid-1-13C 是一种 13C 标记的 L-Glutamic acid。L-Glutamic acid 作为一种兴奋性氨基酸神经递质，为谷氨酸盐受体所有亚型(代谢型红藻氨酸、NMDA 和 AMPA)的激动剂。对 DA 从多巴胺能神经末梢释放的过程有激动作用。
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|---|---|
| 生物活性 |
L-Glutamic acid-1-C is the C-labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
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| 性状 |
Solid
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| IC50 & Target[1][2] |
AMPA Receptor NMDA Receptor
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| 体外研究(In Vitro) |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs. has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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| 参考文献 |
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Giorguieff MF, et al. Presynaptic effect of L-glutamic acid on the release of dopamine in rat striatal slices. Neurosci Lett. 1977 Oct;6(1):73-7.
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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