Methylene Blue|61-73-4|(亚甲蓝; Basic Blue 9; CI-52015; Methylthioninium chloride)-陌孚医药/Medlife

您当前的位置：

Methylene Blue (Synonyms: 亚甲蓝; Basic Blue 9; CI-52015; Methylthioninium chloride)

目录号: PL04077 纯度: ≥98%

CAS No. :61-73-4

商品编号	规格	价格	会员价
PL04077-100mg	100mg	¥618.18	请登录
PL04077-500mg	500mg	¥1050.91	请登录
PL04077-1g	1g	询价	询价
PL04077-5g	5g	询价	询价

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Methylene Blue
中文别名	亚甲兰;碱性蓝 9;碱性湖藍 BB;亚甲基蓝[分光光度分析法用离子缔合试剂];亚甲基蓝溶液;亚甲基蓝溶液 (甲醇溶液) [用于细胞染色];亚甲蓝;Methylene Blue [Ion association reagent for spectrophotometric analysis] 亚甲基蓝[分光光度分析法用离子缔合试剂];Methylene Blue Hydrate 亚甲基蓝水合物;亚甲基蓝;亚甲基蓝(无水);亚甲基蓝（无水）,AR;亚甲基蓝水合物;亚甲蓝 EP标准品;亚甲蓝标准品;甲烯蓝;3,7-双(二甲氨基)吩噻嗪-5-翁氯化物;次甲基蓝;次甲基蓝,三水;碱性湖蓝BB;亚甲基天蓝;亚甲兰,C16H18ClN3S;亚甲蓝( 次甲蓝,美蓝,氯化3,7-双（二甲氨基）吩噻嗪-5-{翁}三水合物);盐基湖蓝BB;3,7-双(二甲氨基)-5-吩噻嗪鎓氯化物溶液 (甲醇溶液);碱性蓝9溶液 (甲醇溶液);亚甲蓝杂质;碱性湖蓝 BB
英文名称	Methylene Blue
英文别名	Basic Blue 9;3,7-Bis(dimethylamino)phenazathionium chloride;Methylene Blue;Ehrlich’s reagent III;Methylene Blue [Ion association reagent for spectrophotometric analysis];Methylene Blue Solution (Methanol Solution)[for Cell Staining];Methylene blue solution;Methylene blue stain for DNA;METHYLENE BLUE, TRIHYDRATE MOLECULAR BIOLOGY C.I.NO 52015;CBLUENO.1;Chromosmon;CI BASIC BLUE 9;CI Direct Blue 53;CI-52015;Evan's Blue;evans blue tetrasodium salt;Methylene Blue Hydrate;Methylene Blue, pure, certified;MethyleneBlueGr;methylthioninium chloride;SWISS BLUE;Tetramethylthionine chloride;Loeffler’s Methylene Blue;Methylene blue stain;Loeffler’s alkaline methylene blue stain solution;Methylene Blue – potassium hydroxide solution;Basic Blue 9 Solution (Methanol Solution);3,7-Bis(dimethylamino)-5-phenothiazinium Chloride Solution (Methanol Solution);Methylthioninium chloride
Cas No.	61-73-4
分子式	C₁₆H₁₈ClN₃S
分子量	319.85
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情

Methylene blue (Basic Blue 9) 是一种鸟苷酸环化酶 (sGC)，单胺氧化酶 A (MAO-A) 和 NO 合酶 (NOS) 抑制剂。Methylene blue 是一种血管加压剂，在医疗中通常用作染料。Methylene blue 通过一氧化氮合成酶/鸟苷酸环化酶信号通路降低脉冲前抑制。Methylene blue 是一种氧化还原循环化合物，能够穿过血脑屏障。Methylene blue 是 Tau 聚集抑制剂。亚甲蓝可减轻脑水肿，减弱小胶质细胞活化，减少神经炎症。

生物活性

Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation.

性状

Solid

IC50 & Target[1][2]

Guanylyl cyclase (sGC).
Monoamine oxidase A (MAO-A).
NO synthase (NOS)

体外研究(In Vitro)

Methylene blue (Basic Blue 9) (4.5 μM; BV2 microglia) alters the immune profile of LPS-activated BV2 microglia and decreases the level of CD14, IL-1β, TNF-α, and CCL2 mRNA. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Methylene blue (Basic Blue 9) (50 and 100 mg/kg; i.p.; once, for 25 min; male NMRI mice) reduces absent prepulse inhibition.
Methylene blue (Basic Blue 9) (20 and 40 mg/kg; p.o.; daily, for 6 months; CaMKIIα-tTA transactivator mice) preserves cognition in mice expressing full-length pro-aggregant human Tau.
Methylene blue (Basic Blue 9) (2 mg/kg; i.v.; once, for 1 d; TBI-treated male BALB/c mice) reduces TBI-induced edema and neuroinflammation and reduces acute depression-like behavior.
Methylene blue (Basic Blue 9) (2 mg/kg; i.v.; once, for 1 d; TBI-treated male BALB/c mice) reduces the percentage of inflammatory factor. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ClinicalTrial

参考文献

[1]. Klamer D, et, al. Phencyclidine-induced behaviour in mice prevented by methylene blue. Basic Clin Pharmacol Toxicol. 2004 Feb;94(2):65-72.
[2]. Hochgr?fe K, et, al. Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau. Acta Neuropathol Commun. 2015 May 10;3:25.

溶解度数据	In Vitro: H₂O : 50 mg/mL (156.32 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation