Aminopterin|54-62-6|(氨基蝶呤; 4-Aminofolic acid; APGA)-陌孚医药/Medlife

您当前的位置：

Aminopterin (Synonyms: 氨基蝶呤; 4-Aminofolic acid; APGA)

目录号: PL04061 纯度: ≥98%

CAS No. :54-62-6

商品编号	规格	价格	会员价
PL04061-5mg	5mg	¥618.18	请登录
PL04061-10mg	10mg	¥989.09	请登录
PL04061-50mg	50mg	¥3461.82	请登录
PL04061-100mg	100mg	¥5538.91	请登录
PL04061-200mg	200mg	询价	询价
PL04061-500mg	500mg	询价	询价
PL04061-10mM*1mLinWater	10mM*1mLinWater	¥680.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Aminopterin
中文别名	氨基蝶呤;癌得宁;4-氨基叶酸;白血宁;氨喋呤;氨基蝶翅素;胺喋呤;甲氨蝶呤杂质B;氨基喋呤;氨喋呤水合物;Aminopterin Hydrate 氨喋呤水合物;an基蝶呤;氨基碟呤;甲氨蝶呤相关物质B USP标准品;4-安蝶林;4-氨基-PGA;4-氨基蝶酰-L-谷氨酸;白血宁,癌得宁,4-氨基叶酸;甲氨蝶呤相关物质B;N-[4-[[(2,4-二氨基-6-蝶啶)甲基]氨基]苯甲酰]-L-谷氨酸;4-氨基-PGA 水合物;4-氨基蝶呤水合物;4-氨基蝶酰-L-谷氨酸水合物
英文名称	Aminopterin
英文别名	Aminopterinum;AGPA;Aminopterine;Aminopterin;N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid;4-Aminofolic Acid;4-amino-4-deoxypteroylglutamate;4-amino-folicaci;4-aminofolicacid[qr];4-amino-pga[qr];4-aminopteroylglutamicacid[qr];4-diamino-6-pteridinyl)methyl)amino)benzoyl)-n-(p-(((l-glutamicaci;ai3-26079[qr];Aminopterin Hydrate;2-(4-((2,4-Diaminopteridin-6-yl)methylamino)-benzamido)pentanedioic acid;(S)-2-{4-[2,4-diaMinopteridin-6yl)MethylaMino]benzoaMido}pentanedioic acid;Aminoperin;aminopteridin;apga;Methotrexate Related CoMpound B;Minopterin;pteramina;(S)-2-{4-[(2,4-Diaminopteridin-6-yl)methylamino]benzamido}pentanedioic acid;4-Aminopteroyl-L-glutamic acid;4-Aminofolic Acid Hydrate;4-Amino-PGA Hydrate;4-Aminopteroyl-L-glutamic Acid Hydrate;4-Amino-PGA;Aminopteridine;A-Ninopterin;4'-Amino-folsaeure;Pteramina [Czech];Folic acid, 4-amino-;4-Amino pteroylglutamic acid;4-Aminopteroylglutamic acid;4'-Desoxy-4'-aminofolsaeure;4-Aminopteroic acid;Kyselina 4-aminolistova [Czech];Aminopteroylglutamic acid;JYB41CTM2Q;4-Amino-4-des;LS-71805;Kyselina 4-aminolistova;A0410;4-26-00-03831 (Beilstein Handbook Reference);4-Amino-4-desoxy-pteroylglutaminsaeure;NCGC00254512-01;54-62-6;EN300-7480753;N-(4-(((2,4-Diamino-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid;N-(P-(((2,4-DIAMINO-6-PTERIDINYL)METHYL)AMINO)BENZOYL)GLUTAMIC ACID;A830273;NSC 739;(4-(((2,4-diaminopteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid;SCHEMBL23086141;UNII-JYB41CTM2Q;Kyselina 4-aminopteroylglutamova [Czech];4kn1;AKOS040759239;Tox21_300627;TVZGACDUOSZQKY-LBPRGKRZSA-N;Aminotrexate;C19H20N8O5;Aminopterin, powder, BioReagent, suitable for cell culture;2-(4-(((2,4-Diaminopteridin-6-yl)methyl)amino)benzamido)pentanedioic acid;(2S)-2-[[4-[[(2,4-Diaminopteridin-6-yl)methyl]amino]benzoyl]amino]pentanedioic Acid (4-Aminofolic Acid, Aminopterin);aminopterin;HSDB 6374;NCGC00348366-01;Aminopterin; (Aminopteridine);Kyselina N-(p-((2,4-diamino-6-pteridinyl)methyl)benzoyl)-L(+)-glutamova [Czech];54-62-6 (free acid);BDBM50367055;Kyselina N-(p-((2,4-diamino-6-pteridinylmethyl)amino)benzoyl)-L(+)-glutamova [Czech];APGA;L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)amino)benzoyl)-;NSC-739;Aminofolic acid, 4-;Kyselina 4-aminopteroylglutamova;4-Amino Folic Acid;DB08878;AMINOPTERIN [MI];CS-0003421;(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl]amino}phenyl)formamido]pentanedioic acid;DTXCID802588;NSC739;Aminopterin, powder;HY-14518;N-(4-(((2,4-Diamino-6-pteridyl)-methyl)amino)benzoyl)-L-glutamic acid;AMINOPTERIN [WHO-DD];CHEBI:22526;Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)amino)benzoyl)-, L-;(2S)-2-[[[4-[(2,4-diamino-6-pteridinyl)methylamino]phenyl]-oxomethyl]amino]pentanedioic acid;N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid;NCGC00015038-03;4-Amino-4-deoxypteroylglutamate;Kyselina N-(p-((2,4-diamino-6-pteridinyl)m...
Cas No.	54-62-6
分子式	C₁₉H₂₀N₈O₅
分子量	440.41
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情

Aminopterin (4-Aminofolic acid)，叶酸的 4-氨基衍生物，是叶酸 (folic acid) 拮抗剂。Aminopterin 催化叶酸还原为四氢叶酸，Aminopterin 竞争性抑制二氢叶酸还原酶 (DHFR)，K_i 值为 3.7 pM。Aminopterin 具有抗癌和免疫抑制活性。Aminopterin 用于研究儿童白血病。

生物活性

Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a K i of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia.

性状

Solid

体外研究(In Vitro)

The IC50 value of Aminopterin (4-Aminofolic acid) against CCRF-CEM cells during 72 h of exposure is 4.4 nM.
Aminopterin (4-Aminofolic acid) produces a marked inhibition of mitosis in low concentrations in human leukemic leukocytes. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；In solvent -80°C 6 months

ClinicalTrial

参考文献

[1]. MEYER LM, et al. Aminopterin, a folic acid antagonist, in the treatment of leukemia. Am J Clin Pathol. 1949 Feb;19(2):119-26.
[2]. Rosowsky A, et al. Synthesis and in vitro antifolate activity of rotationally restricted aminopterin and methotrexate analogues. J Med Chem. 2004 Dec 30;47(27):6958-63.

溶解度数据	In Vitro: DMSO : 14.71 mg/mL (33.40 mM; Need ultrasonic)H₂O : 5 mg/mL (11.35 mM; ultrasonic and adjust pH to 8 with NaOH)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation