DDO-5936|2355377-13-6|-陌孚医药/Medlife

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DDO-5936

目录号: PL03826 纯度: ≥95%

CAS No. :2355377-13-6

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中文名称	DDO-5936
英文名称	DDO-5936
英文别名	N-[4-[[2-(1-Pyrrolidinyl)-4-pyrimidinyl]amino]phenyl]-N-[(2,4,6-trimethylphenyl)sulfonyl]glycine;2-(2,4,6-trimethyl-N-(4-((2-(pyrrolidin-1-yl)pyrimidin-4-yl)amino)phenyl)phenylsulfonamido)acetic acid;BDBM50520387;2-[4-[(2-pyrrolidin-1-ylpyrimidin-4-yl)amino]-N-(2,4,6-trimethylphenyl)sulfonylanilino]acetic acid;DDO-5936
Cas No.	2355377-13-6
分子式	C₂₅H₂₉N₅O₄S
分子量	495.59
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	DDO-5936 是一种有效且特异的 Hsp90-Cdc37 PPI 抑制剂。DDO-5936 可用于大肠癌的研究。
生物活性	DDO-5936 is a potent and specific Hsp90-Cdc37 PPI inhibitor. DDO-5936 can be used for the research of colorectal cancer.
性状	Solid
IC50 & Target[1][2]	Hsp90-Cdc37 PPI
体外研究(In Vitro)	DDO-5936 is a Hsp90-Cdc37 PPI inhibitor with potency and specificity through binding to a critical site on Hsp90 involving Glu47. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	DDO-5936 (0~80 mg/kg; p.o.) shows effect at the high dose group. DDO-5936 is well tolerated for the absence of serious weight loss. DDO-5936 high dose groups show that tumor cells in the xenografts decreased significantly. DDO-5936 shows limited oral efficiency. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Wang L, et al. Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 as Orally Active Inhibitors for the Treatment of Colorectal Cancer. J Med Chem. 2020;63(3):1

溶解度数据	In Vitro: DMSO : 12.5 mg/mL (25.22 mM; ultrasonic and warming and heat to 60°C)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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