5-Iminodaunorubicin hydrochloride|67324-99-6|-陌孚医药/Medlife

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5-Iminodaunorubicin hydrochloride

目录号: PL03757 纯度: ≥95%

CAS No. :67324-99-6

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中文名称	5-Iminodaunorubicin hydrochloride
英文名称	5-Iminodaunorubicin hydrochloride
英文别名	12-Iminodaunorubicin HCl;5-Iminodaunorubicin hydrochloride
Cas No.	67324-99-6
分子式	C₂₇H₃₁ClN₂O₉
分子量	563.00
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	5-Iminodaunorubicin hydrochloride 是一种醌改性蒽环类药物，具有抗肿瘤活性。5-Iminodaunorubicin hydrochloride 在癌细胞中可诱导 DNA 链断裂。
生物活性	5-Iminodaunorubicin hydrochloride is a quinone-modified anthracycline that retains antitumor activity. 5-Iminodaunorubicin hydrochloride produces protein-concealed DNA strand breaks in cancer cells.
性状	Solid
体外研究(In Vitro)	In mouse leukemia L1210 cells, 5-Iminodaunorubicin produces protein-concealed DNA strand breaks. Many of the 5-iminodaunorubicin breaks may arise from apposed single-strand breaks (i.e., double-strand breaks). has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	In rat, 5-Iminodaunorubicin (5-ID; 1-16 mg/kg) treatment produces widening of the QRS complex, increased R- and S-wave voltage, and prolonged the Q alpha T interval. And the quinone redox cycling is suppressed in 5-Iminodaunorubicin. 5-Iminodaunorubicin shows lower cardiotoxic. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. R A Jensen, et al. Electrocardiographic and transmembrane potential effects of 5-iminodaunorubicin in the rat. Cancer Res. 1984 Sep;44(9):4030-9. [2]. L A Zwelling, et al. Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukemia L1210 cells: comparison with adriamycin and 4-(9-acridinylamino)methanesulfon-m-anisidide. Cancer Res. 1982 Jul;42(7):2687-91.

溶解度数据	In Vitro: DMSO : 230 mg/mL (408.53 mM; Need ultrasonic)H₂O : 8.33 mg/mL (14.80 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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