PW0787 是一种有效的，选择性的，具有口服活性的，可透过血脑屏障的 GPR52 激动剂 (EC₅₀=135 nM)。PW0787 抑制精神刺激行为。

PW0787 is a potent, selective, orally active, and brain-penetrant GPR52 agonist (EC 50 =135 nM). PW0787 suppresses psychostimulant behavior.

Solid

EC50: 135 nM (GPR52)

PW0787 (0.3, 1, 3, or 10 mg/kg; IP) displays antipsychotic-like activity by significantly inhibiting amphetamine-induced hyperlocomotor behavior in mice.
PW0787 is evaluated in rats after a single dose of 20 mg/kg by oral (PO) or 10 mg/kg by intravenous (IV) administration. PW0787 has excellent plasma exposure after PO (AUC 0-inf = 13,749 ng?h/mL) and IV dosing (AUC 0-inf =9030 ng?h/mL), as well as high maximum serum concentration following PO (C max =3407 ng/mL) and IV administration (C max =6726 ng/mL). Additionally, PW0787 displays good volume of plasma distribution (V ss =1.5 L/kg) and acceptable plasma clearance (CL=1.1 L/h/kg) after 10 mg/kg IV. Excellent oral bioavailability (F) with the value of 76% is observed.

Room temperature in continental US; may vary elsewhere.

4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

[1]. Wang P, et al. Discovery of Potent and Brain-Penetrant GPR52 Agonist that Suppresses Psychostimulant Behavior. J Med Chem. 2020;63(22):13951-13972.

In Vitro: DMSO : 50 mg/mL (108.60 mM; Need ultrasonic)配制储备液