YUM70|423145-35-1|-陌孚医药/Medlife

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YUM70

目录号: PL03737 纯度: ≥98%

CAS No. :423145-35-1

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中文名称	YUM70
英文名称	YUM70
英文别名	MLS000548411;SMR000172091;N-[Benzo[1,3]dioxol-5-yl-(5-chloro-8-hydroxy-quinolin-7-yl)-methyl]-butyramide;BAS 02169251;Oprea1_596028;Oprea1_626646;BDBM77529;cid_3138755;HMS2575N03;DNDI1417995;N-[1,3-benzodioxol-5-yl-(5-chloro-8-hydroxyquinolin-7-yl)methyl]butanamide;N-[1,3-benzodioxol-5-yl-(5-chloro-8-hydroxy-7-quinolinyl)methyl]butanamide;N-[1,3-benzodioxol-5-yl-(5-chloro-8-hydroxy-7-quinolyl)methyl]butyramide;N-(Benzo[d][1,3]dioxol-5-y;YUM70
Cas No.	423145-35-1
分子式	C₂₁H₁₉ClN₂O₄
分子量	398.84
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	YUM70 是一种有效和选择性的葡萄糖调节蛋白 78 (GRP78) 抑制剂，抑制全长蛋白的 GRP78 ATPase 活性的 IC₅₀ 值为 1.5 μM。YUM70 可诱导内质网 (ER) 应激介导的胰腺癌细胞凋亡。YUM70 在胰腺癌异种移植模型中也具有体内功效。
生物活性	YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC 50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model.
性状	Solid
IC50 & Target[1][2]	IC50: 1.5 μM (glucose-regulated protein 78)
体外研究(In Vitro)	YUM70 shows selective cytotoxicity for MIA PaCa-2, PANC-1, BxPC-3 cells (IC50=2.8, 4.5, and 9.6 μM, respectively) over normal pancreatic tissue-derived HPNE cells (IC50>30 μM). YUM70 (5 μM; 24 h) induces endoplasmic reticulum (ER) stress-mediated apoptosis of MIA PaCa-2cells. has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis
体内研究(In Vivo)	YUM70 (30 mg/kg; i.p. 5 days a week for 7 weeks) inhibits tumor growth in a MIA PaCa-2 xenograft model. YUM70 (15 mg/kg; i.v.) exhibits t 1/2 (1.40 h), CL (724.04 mL/h/kg), and V ss (1162.73 mL/kg) in mice. YUM70 (30 mg/kg; p.o.) exhibits bioavailability (6.71%), t 1/2 (2.74 h), and CL (9230.15 mL/h/kg) in mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Samanta S, et, al. The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer. Cancer Res. 2021 Feb 2;canres.1540.2020.

溶解度数据	In Vitro: DMSO : 100 mg/mL (250.73 mM; Need ultrasonic)配制储备液

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