CC-90001|1403859-14-2|-陌孚医药/Medlife

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CC-90001

目录号: PL03735 纯度: ≥99%

CAS No. :1403859-14-2

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中文名称	CC-90001
英文名称	CC-90001
英文别名	2-(tert-butylamino)-4-[[(1R,3R,4R)-3-hydroxy-4-methylcyclohexyl]amino]pyrimidine-5-carboxamide;2-(tert-butylamino)-4-{[(1R,3R,4R)-3-hydroxy-4-methylcyclohexyl]amino}pyrimidine-5-carboxamide;2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide;2-(tert-butylamino)-4-((1R,3R,4R)-3-hydroxy-4-methylcyclohexylamino)pyrimidine-5-carboxamide;CC-90001
Cas No.	1403859-14-2
分子式	C₁₆H₂₇N₅O₂
分子量	321.42
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情

CC-90001 是一种有效，选择性和具有口服活性的 c-Jun N 末端激酶 (JNK) 抑制剂。CC-90001 在基于细胞的模型中显示出对 JNK1 的选择性是 JNK2 的 12.9 倍。CC-90001 可用于特发性肺纤维化的研究。

生物活性

CC-90001 is a potent, selective and orally active inhibitor of c-Jun N-terminal kinase (JNK). CC-90001 shows 12.9-fold selectivity for JNK1 over JNK2 in a cell-based model. CC-90001 can be used for the research of idiopathic pulmonary fibrosis.

性状

Solid

IC50 & Target[1][2]

JNK1 JNK2

体外研究(In Vitro)

CC-90001 blocks LPS-induced c-jun phosphorylation with an EC50 of 480 nM in cellular assays.
CC-90001 is 12.9-fold more potent for JNK1 inhibition than JNK2 using JNK1 and JNK2 knockout fibroblasts. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

CC-90001 (3 mg/kg b.i.d.) reduces the development of fibrosis, as evidenced by a 48% reduction in collagen and a 53% reduction in α-smooth muscle actin (α-SMA) in a steatohepatitis model.
CC-90001 decreases multiple measures of lung collagen and reduces disease induced increases in α-SMA to nearly baseline levels in a house dust mite model of lung fibrosis. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；In solvent -80°C 6 months

ClinicalTrial

参考文献

[1]. Bennett B, et, al. CC-90001, a Second Generation Jun N-Terminal Kinase (JNK) Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine 2017; 195:A5409.
[2]. Kolb M, et, al. Therapeutic targets in idiopathic pulmonary fibrosis. Respir Med. 2017 Oct;131:49-57.

溶解度数据	In Vitro: DMSO : 125 mg/mL (388.90 mM; Need ultrasonic)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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