ERK-IN-3 benzenesulfonate|2055597-39-0|(ERK-IN-3 benzenesulfonate)-陌孚医药/Medlife

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ERK-IN-3 benzenesulfonate (Synonyms: ERK-IN-3 benzenesulfonate)

目录号: PL03617 纯度: ≥98%

CAS No. :2055597-39-0

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中文名称	ERK-IN-3 benzenesulfonate
英文名称	ERK-IN-3 benzenesulfonate
英文别名	1H-Imidazole-4-carboxamide, N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-, compd. with benzenesulfonate (1:1);ASN007 benzenesulfonate
Cas No.	2055597-39-0
分子式	C₂₈H₃₁ClFN₇O₅S
分子量	632.11
包装储存	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	ERK-IN-3 benzenesulfonate 是一种有效和具有口服活性的 ERK 抑制剂。 ERK-IN-3 benzenesulfonate 以较低的 IC₅₀ 值抑制 ERK1/2。 ERK-IN-3 benzenesulfonate 可用于研究由 RAS 突变驱动的癌症。
生物活性	ERK-IN-3 benzenesulfonate is a potent and orally active inhibitor of ERK. ERK-IN-3 benzenesulfonate inhibits ERK1/2 with low single-digit nM IC 50 values. ERK-IN-3 benzenesulfonate can be used for the research of cancers driven by RAS mutations.
性状	Solid
IC50 & Target[1][2]	ERK1 ERK2
体外研究(In Vitro)	ERK-IN-3 inhibits the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines. ERK-IN-3 showes single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	ERK-IN-3 (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice and was well tolerated at efficacious doses. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Sanjeeva PR, et, al. Abstract B150: ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. Molecular Cancer Therapeutics. 2018 Jan; 17(1).

溶解度数据	In Vitro: DMSO : 320 mg/mL (506.24 mM; Need ultrasonic)H₂O : 100 mg/mL (158.20 mM; Need ultrasonic)配制储备液

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