Indisulam|165668-41-7|(E 7070)-陌孚医药/Medlife

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Indisulam (Synonyms: E 7070)

目录号: PL03605 纯度: ≥99%

CAS No. :165668-41-7

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中文名称	Indisulam
中文别名	N-(3-氯-1H-吲哚-7-基)-1,4-苯二磺酰胺;2-[N-(2-氰乙基)-4-[(2,6-二氯-4-硝基苯基)偶氮]苯胺基]乙酸乙酯
英文名称	Indisulam
英文别名	Indisulam;N-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide;4-N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide;1,4-Benzenedisulfonamide,N-(3-chloro-1H-indol-7-yl);E7070;Indisulam (IND);N-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide;N-(3-chloro-1H-indol-7-yl)-4-sulfamoylbenzenesulfonamide;N1-(3-Chloro-1H-indol-7-yl)-1,4-benzenedisulfonamide;E-7070;ER-35744;IndisulaM (E7070);IndisulaM (E7070) (ER-35744);N1-(3-Chloro-1H-indol-7-yl)benzene-1,4-disulfonamide;1,4-Benzenedisulfonamide, N-(3-chloro-1H-indol-7-yl)-;E 7070;WJ98J3NM90;N-(3-Chloro-1H-indol-7-yl)benzene-1,4disulfonamide;Indisulam (USAN/INN);N-(3-chl;INDISULAM
Cas No.	165668-41-7
分子式	C₁₄H₁₂ClN₃O₄S₂
分子量	385.85
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情

Indisulam (E 7070) 是一种碳酸酐酶抑制剂，具有抗癌活性。Indisulam (E 7070) 是细胞周期 G1 期的靶向化合物。Indisulam (E 7070) 通过抑制 CDK2 和周期蛋白 E 的激活，引起 G1/S 转化被阻滞。Indisulam (E 7070) 通过募集 DCAF15 诱导 RBM39 降解来靶向剪接。

生物活性

Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15.

性状

Solid

IC50 & Target[1][2]

Carbonic anhydrase.

体外研究(In Vitro)

Indisulam (E7070, 0-50 μg/mL, 12-48 h) causes cell cycle perturbation in the G1 phase in a time- and dose-dependent manner, potentially leading to cell death. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Cycle Analysis

体内研究(In Vivo)

Indisulam (E7070, 12.5, 25, 50 (100) mg/kg) shows an antitumour spectrum in human cancer models. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female BALB/c nu/nu mice aged 7 weeks

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；In solvent -80°C 6 months

ClinicalTrial

参考文献

[1]. Ozawa Y, et al. E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo. Eur J Cancer. 2001 Nov;37(17):2275-82.
[2]. Abbate F, et al. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg Med Chem Lett. 2004 Jan 5;14(1):217-23.

溶解度数据	In Vitro: DMSO : 100 mg/mL (259.17 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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