21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione|37413-91-5|-陌孚医药/Medlife

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21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione

目录号: PL03591 纯度: ≥99%

CAS No. :37413-91-5

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中文名称	21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
中文别名	21-羟基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯;21-乙酰氧基-孕甾-1,4,9(11),16-四烯-3,20-二酮;醋酸四烯物;醋酸四烯物 3TR;醋酸四烯物(3TR);四烯物;21-乙酰氧基孕甾-1,4,9(11),16-四烯-3,20-酮
英文名称	21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
英文别名	21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione;21-Hydroxypregna-1,4,9(11),16-tetraene-3,20-dione 21-acetate;21-(Acetyloxy)-pregna-1,4,9(11),16-tetraene-3,20-dione;2-((8S,10S,13S,14S)-10,13-Dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate;21-HYDROXYPREGNA-1,4,9(11),16-TETRAENE-3,20-DIONE-21-ACETATE;3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate;16-tetraene-3,20-dione 21-acetate;21-(Acetyloxy)pregna-1,4,9(11),16-tetraene-3,20-dione;21-Acetoxy-pregna-1,4,9(11),16-tetraen-3,20-dion;21-acetoxy-pregna-1,4,9(11),16-tetraene-3,20-dione;21-hydroxy-pregna-1,4,9(11),16-tetraene-3,20-dione 21-acetate;3,20-dioxopregna-1,4,9(11),16-tetraen-21-yl ace;EINECS 253-497-3;Tetraene Acetate
Cas No.	37413-91-5
分子式	C₂₃H₂₆O₄
分子量	366.45
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione 是 delta 9,11 类固醇类合成的中间体 (intermediate)，如 Vamorolone (HY-109017)。delta 9,11 steroids 是糖皮质激素的修饰后的产物，具有抗炎 (anti-inflammatory) 特性。delta 9,11 类固醇类可以用作保护细胞损伤(脂质过氧化)和抑制新生血管的试剂。
生物活性	21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone (HY-109017). The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. The delta 9,11 steroids are agents for protection against cell damage (lipid peroxidation) and inhibition of neovascularization.
性状	Solid
体外研究(In Vitro)	Δ9,11 derivatives are designed and developed to stably incorporate into cell membranes and inhibit lipid peroxidation without glucocorticoid or mineralocorticoid activities, thus avoiding side effects associated with traditional corticosteroids. VBP15 acts as a lead compound due to potent NF-κB inhibition and GR translocation similar to prednisone and dexamethasone, lack of transactivation properties, and good bioavailability. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Erica K M Reeves, et al. VBP15: preclinical characterization of a novel anti-inflammatory delta 9,11 steroid. Bioorg Med Chem

溶解度数据	In Vitro: DMSO : 100 mg/mL (272.89 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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