CMS-121|1353224-53-9|-陌孚医药/Medlife

您当前的位置：

CMS-121

目录号: PL03538 纯度: ≥98%

CAS No. :1353224-53-9

商品编号	规格	价格	会员价
PL03538-5mg	5mg	¥1360.00	请登录
PL03538-10mg	10mg	¥2225.45	请登录
PL03538-25mg	25mg	¥4450.91	请登录
PL03538-50mg	50mg	¥7170.91	请登录
PL03538-100mg	100mg	¥11498.18	请登录
PL03538-200mg	200mg	询价	询价
PL03538-500mg	500mg	询价	询价
PL03538-10mM*1mLinDMSO	10mM*1mLinDMSO	¥1496.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	CMS-121
英文名称	CMS-121
英文别名	4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol;4-[4-(Cyclopentyloxy)quinolin-2-yl]benzene-1,2-diol;CMS121;4-[4-(Cyclopentyloxy)-2-quinolinyl]-1,2-benzenediol;CMS-121
Cas No.	1353224-53-9
分子式	C₂₀H₁₉NO₃
分子量	321.37
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

CMS-121 是一种喹诺酮衍生物，也是一种口服活性的乙酰辅酶 A 羧化酶 1 (acetyl-CoA carboxylase 1, ACC1) 抑制剂。CMS-121 分别以 EC₅₀ 值为 7 nM 和 200 nM 来保护 HT22 细胞免受缺血和氧化损伤。CMS-121 具有强大的神经保护，抗炎，抗氧化和肾保护作用。

生物活性

CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC 50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities.

性状

Solid

IC50 & Target[1][2]

Acetyl-CoA carboxylase 1 (ACC1)

体外研究(In Vitro)

CMS-121 (1 μM; 4 hours; HT22 cells) treatment increases the phosphorylation of ACC1 at serine 79. CMS-121 can increase acetyl-CoA in cells. has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis

体内研究(In Vivo)

CMS-121 (~20 mg/kg; oral administration; daily; for 4 months; female SAMP8 mice) treatment reduces cognitive decline as well as metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Currais A, et al. Elevating acetyl-CoA levels reduces aspects of brain aging. Elife. 2019 Nov 19;8. pii: e47866.
[2]. Chiruta C, et al. Chemical modification of the multitarget neuroprotective compound fisetin. J Med Chem. 2012 Jan 12;55(1):378-89.
[3]. Prior M, et al. Back to the future with phenotypic screeni

溶解度数据	In Vitro: DMSO : 50 mg/mL (155.58 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation