IM156|1422365-94-3|(IM156; HL156A; HL271 acetate)-陌孚医药/Medlife

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IM156 (Synonyms: IM156; HL156A; HL271 acetate)

目录号: PL03546 纯度: ≥99%

CAS No. :1422365-94-3

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PL03546-200mg	200mg	询价	询价
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中文名称	IM156
中文别名	N-（N-（4-（三氟甲氧基）苯基）氨基甲酰）吡咯烷-1-羧酸氨基甲酰胺乙酸酯
英文名称	IM156
英文别名	IM156;HL271 acetate;HL156A;8MS59W493C;acetic acid;N'-[N'-[4-(trifluoromethoxy)phenyl]carbamimidoyl]pyrrolidine-1-carboximidamide;N-(Imino((4-(trifluoromethoxy)phenyl)amino)methyl)-1-pyrrolidinecarboximidamide, acetate;1-Pyrrolidinecarboximidamide, N-(imino((4-(trifluoromethoxy)phenyl)amino)methyl)-, acetate (1:1);Unii-8MS59W493C
Cas No.	1422365-94-3
分子式	C₁₅H₂₀F₃N₅O₃
分子量	375.35
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情

IM156 (HL156A; HL271 acetate) 是二甲双胍 (HY-B0627) 的化学衍生物，是一种强效的，具有口服活性的 AMPK 激活剂。IM156 在动物模型中可缓解与年龄相关的认知障碍。IM156 是一种有效的氧化磷酸化 (OXPHOS) 抑制剂，可用于实体肿瘤的研究。

生物活性

IM156 (HL156A; HL271 acetate), a chemical derivative of Metformin (HY-B0627), is a potent and orally active AMPK activator that increases AMPK phosphorylation. IM156 attenuates aging-associated cognitive impairment in animal model. IM156 is a potent oxidative phosphorylation (OXPHOS) inhibitor which can be used for the research of solid tumors.

性状

Solid

IC50 & Target[1][2]

AMPK, OXPHOS

体外研究(In Vitro)

IM156 (0.31-10 μM) phosphorylates AMPKα1 Thr172 in a dose- and time-dependent manner in NIH3T3 mouse fibroblast cells.
IM156 does not affect the expression of key factors involved in glucose homeostasis such as glucose-6-phosphatase (G6pase) or phosphoenolpyruvate carboxykinase 1 (Pck1).
has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis

体内研究(In Vivo)

IM156 does not affect metabolic regulation assessed by body weight, blood glucose, insulin levels and lipid metabolite content in mice with diet-induced obesity.
IM156 (50 mg/kg; for 2 months) does not affect body weight, general locomotion, or anxiety.
IM156 significantly attenuates the aging-induced decline in novel object recognition memory and spatial working memory.
IM156 significantly increases AMPK activation in the hippocampus of aged mice.
has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

ClinicalTrial

参考文献

[1]. Row H, et al. HL271, a novel chemical compound derived from metformin, differs from metformin in its effects on the circadian clock and metabolism. Biochem Biophys Res Commun. 2016 Jan 15;469(3):783-9.
[2]. Bang E, et al. The Improving Effect of HL271, a Chemical Derivative of Metformin, a Popular Drug for Type II Diabetes Mellitus, on Aging-induced Cognitive Decline. Exp Neurobiol. 2018 Feb;27(1):45-56.

溶解度数据	In Vitro: DMSO : 100 mg/mL (266.42 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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