CG347B|1598426-03-9|-陌孚医药/Medlife

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CG347B

目录号: PL03525 纯度: ≥98%

CAS No. :1598426-03-9

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中文名称	CG347B
英文名称	CG347B
英文别名	CG347B;Ethyl 2-((1-phenylcyclopropyl)amino)pyrimidine-5-carboxylate;2-[(1-Phenylcyclopropyl)amino]-5-pyrimidinecarboxylic acid ethyl ester;ethyl 2-[(1-phenylcyclopropyl)amino]pyrimidine-5-carboxylate;2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid ethyl ester;C1(=CC=CC=C1)C1(CC1)NC1=NC=C(C=N1)C(=O)OCC
Cas No.	1598426-03-9
分子式	C₁₆H₁₇N₃O₂
分子量	283.33
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	CG347B 是一种选择性的 HDAC6 抑制剂，也参与合成其他金属酶抑制剂的合成。HDAC6 抑制剂可用于肿瘤学、免疫学和神经学的研究。
生物活性	CG347B is a selective HDAC6 inhibitor, also involves in synthesis of other metalloenzyme inhibitors. HDAC6 inhibitors can be used for oncology, immunology, and neurology research.
性状	Solid
IC50 & Target[1][2]	HDAC6
体外研究(In Vitro)	HtrA1 is identified as a Cisplatin (HY-17394, CDDP) resistance-related gene in NSCLC cells, while CG347B shows no effect on normalized mRNA expression or protein level of HtrA1 in NCI-H460 (CDDP-resistant) cells. CG347B (200 nM; 48 h) slightly rescues the Foxp3 expression inhibition induced by IL-4 (15 ng/mL), indicating a potential inhibition happens on histone deacetylation in naive CD4 T cells from WT B6 mice cultured under Treg-polarizing conditions (for 1-3 d). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Wang W, et al. Characterization of a novel HDAC/RXR/HtrA1 signaling axis as a novel target to overcome cisplatin resistance in human non-small cell lung cancer. Mol Cancer. 2020 Sep 2;19(1):134. [2]. Christopher M. YATES. Metalloenzyme inhibitor compounds. WO2018165520A1. [3]. Cui J, et al. IL-4 inhibits regulatory T cells differentiation by HDAC9-medi

溶解度数据	In Vitro: DMSO : 250 mg/mL (882.36 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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