Cletoquine oxalate|14142-64-4|(Desethylhydroxychloroquine oxalate)-陌孚医药/Medlife

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Cletoquine oxalate (Synonyms: Desethylhydroxychloroquine oxalate)

目录号: PL03510 纯度: ≥99%

CAS No. :14142-64-4

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中文名称	Cletoquine oxalate
中文别名	氯托喹草酸;N-乙酰叶酸-D4
英文名称	Cletoquine oxalate
英文别名	Cletoquine Oxalate;2-[4-[(7-chloroquinolin-4-yl)amino]pentylamino]ethanol,oxalic acid;(+/-)-Desethylhydroxychloroquine Oxalate;2-[[4-[(7-Chloro-4-quinolinyl)amino]pentyl]amino]ethanol Oxalate;AG-D-82485;CTK8F8716;FT-0665091
Cas No.	14142-64-4
分子式	C₁₆H₂₂N₃OCl^.C₂H₂O₄
分子量	397.85
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Cletoquine oxalate (Desethylhydroxychloroquine oxalate) 是 Hydroxychloroquine 的主要活性代谢产物，是由 CYP2D6，CYP3A4，CYP3A5 和 CYP2C8 同工酶在肝脏中形成的。Cletoquine oxalate 也是一种 Chloroquine 衍生物，具有抗基孔肯雅热病毒 (CHIKV) 的能力。Cletoquine oxalate 具有抗疟作用，并可用于自身免疫性疾病的研究。
生物活性	Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment.
性状	Solid
IC50 & Target[1][2]	Chikungunya virus (CHIKV)
体内研究(In Vivo)	Hydroxychloroquine (5 mg/kg intravenously) is administered to BALB/c mice for blood and tissue to determine the content of Cletoquine (Desethylhydroxychloroquine). The tissue to blood concentration ratio (Kp) is ≥1, indicating accumulation of Cletoquine in tissues. The Cletoquine Kp ratio for the various tissues are observed in the descending order of liver (114.3)>kidney (24.4)>spleen (19.3)>lungs (16.5)>heart (5.5). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Kumar M, et al. Molecular docking studies of chloroquine and its derivatives against P23pro-zbd domain of chikungunya virus: Implication in designing of novel therapeutic strategies. J Cell Biochem. 2019 Oct;120(10):18298-18308. [2]. Charlier B, et al. Development of a novel ion-pairing HPLC-FL method for the separation and quantification of hydroxychloroquine and its metabolites in whole blood. Biomed Chromatogr. 2018 Aug;32(8):e4258.

溶解度数据	In Vitro: DMSO : 5 mg/mL (12.57 mM; Need ultrasonic)配制储备液

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