4-Methylamino antipyrine hydrochloride|856307-27-2|-陌孚医药/Medlife

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4-Methylamino antipyrine hydrochloride

目录号: PL03494

CAS No. :856307-27-2

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中文名称	4-Methylamino antipyrine hydrochloride
中文别名	安乃近钠杂质C;安乃近杂质C;安乃近杂质C(EP) 标准品
英文名称	4-Methylamino antipyrine hydrochloride
英文别名	Imp. C (EP) as Hydrochloride:4-Methylamino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one Hydrochloride(4-Methylaminophenazone Hydrochloride);1,2-Dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one monohydrochloride;N-Methylaminophenazone;Noramidopyrine hydrochloride;Noraminopyrine hydrochloride;4-Methylamino antipyrine (hydrochloride);1,5-dimethyl-4-(methylamino)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one hydrochloride;4-Methylaminophenazone Hydrochloride;T4070;4-Methylaminoantipyrine hydrochloride, analytical standard;1,5-dimethyl-4-(methylamino)-2-phenylpyrazol-3-one;hydrochloride;4-Methylamino-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one Hydrochloride (4-Methylaminophenazone Hydrochloride)
Cas No.	856307-27-2
分子式	C₁₂H₁₆ClN₃O
分子量	253.73
包装储存	Please store the product under the recommended conditions in the Certificate of Analysis.

产品详情	4-Methylamino antipyrine hydrochloride 是一种 Metamizole 的活性代谢产物。Metamizole 是吡唑啉酮类非甾体抗炎药 (NSAID)，是一种有效的 COX 抑制剂。Metamizole 是一种非阿片类化合物，可用于疼痛和发烧的研究。
生物活性	4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic drug and can be used for pain and fever. 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties.
IC50 & Target[1][2]	COX
体外研究(In Vitro)	Metamizole is a prodrug which, at room temperature and in an atmosphere with oxygen, is spontaneously, nonenzymatically converted to 4-Methylamino antipyrine. Subsequently, the N-methyl side chain of 4-Methylamino antipyrine is oxidized to yield 4-formylaminoantipyrine, which is further converted to 4-aminoantipyrine. Metamizole in aqueous solution and in the presence of oxygen consists of a group of several pyrazolone derivatives of which 4-Methylamino antipyrine is pharmacologically the most important. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	The aim of this study is to assess the pharmacokinetics of its active metabolites 4-Methylamino antipyrine in male piglets after a single intramuscular injection of Metamizole. Eight healthy male piglets are administered Metamizole (100 mg/kg) intramuscularly. 4-Methylamino antipyrine plasma concentrations are quantitatively detectable from 0.25 to 48 h. The average maximum concentration of 4-Methylamino antipyrine is of 47.59 mg/mL. The average half-lives is 8.57 h for 4-Methylamino antipyrine. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Burmańczuk A, et al. Pharmacokinetic investigations of the marker active metabolites 4-methylamino-antipyrine and 4-amino-antipyrine after intramuscular injection of metamizole in healthy piglets. J Vet Pharmacol Ther. 2016 Dec;39(6):616-620. [2]. Campos C1, et al. Regulation of cyclooxygenase activity by metamizol. Eur J Pharmacol. 1999 Aug 13;378(3):339-47.

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