Beclometasone dipropionate|5534-09-8|(二丙酸倍氯米松; Beclomethasone dipropionate )-陌孚医药/Medlife

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Beclometasone dipropionate (Synonyms: 二丙酸倍氯米松; Beclomethasone dipropionate )

目录号: PL03492 纯度: ≥99%

CAS No. :5534-09-8

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中文名称	Beclometasone dipropionate
中文别名	丙酸倍氯米松;氯地米松;倍氯美松双丙酸酯;二丙酸培氯松;二丙酸氯地米松;必酮碟;安得新;丙酸倍美松;倍氯米松二丙酸酯;丙酸倍氯米松 GMP;倍氯米松二丙酸盐;Beclometasone Dipropionate 倍氯米松二丙酸盐;倍氯米松;倍氯米松二丙酸酯标准品;倍氯米松双丙酸酯;丙酸倍氯米松,USP,EP,BP;丙酸倍氯米松,倍氯米松双丙酸酯;丙酸倍氯米松标准品;丙酸倍氯米松标准品(JP);丙酸倍氯米松二水合物标准品;丙酸倍氯米松杂质;二丙酸倍氯米松;倍氯米松丙酸酯;9-氯-11β,17,21-三羟基-16β-甲基孕甾-1,4-二烯-3,20-二酮-17,21-二丙酸酯;丙酸倍氯米松,医药级,纯度:>99%
英文名称	Beclometasone dipropionate
英文别名	Beclometasone Dipropionate;Beclometasone;Beclomethasone dipropionate;9-Chloro-11b,17,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate;Aldecin
Cas No.	5534-09-8
分子式	C₂₈H₃₇ClO₇
分子量	521.05
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Beclometasone dipropionate 是 Beclometasone 的前体药物，是口服有效的糖皮质激素受体激动剂。Beclometasone dipropionate 通过糖皮质激素受体发挥作用，抑制炎症和过度增殖。Beclometasone dipropionate 可用于哮喘研究。

生物活性

Beclometasone dipropionate, the prodrug of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate can be used for asthma .

性状

Solid

IC50 & Target[1][2]

iNOS

体外研究(In Vitro)

Beclometasone dipropionate (1-100 nM; 20 min) inhibits STAT-1 expression and reduces the levels of iNOS, ROS and NT generated by rhIL-17A in 16HBE cells. has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis

体内研究(In Vivo)

Beclometasone dipropionate (150 μg/kg; nebulization; male BALB/c mice) relieves asthma and decreases total cell number and relative eosinophil number. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Hrvaci? B, et, al. Applicability of an ultrasonic nebulization system for the airways delivery of beclomethasone dipropionate in a murine model of asthma. Pharm Res. 2006 Aug;23(8):1765-75.
[2]. Montalbano AM, et, al. Beclomethasone dipropionate and formoterol reduce oxidative/nitrosative stress generated by cigarette smoke extracts and IL-17A in human bronchial epithelial cells. Eur J Pharmacol. 2013 Oct 15;718(1-3):418-27.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (191.92 mM)H₂O : < 0.1 mg/mL (ultrasonic) (insoluble)

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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