Bendamustine|16506-27-7|(SDX-105 free base)-陌孚医药/Medlife

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Bendamustine (Synonyms: SDX-105 free base)

目录号: PL03485 纯度: ≥98%

CAS No. :16506-27-7

商品编号	规格	价格	会员价
PL03485-5mg	5mg	¥1112.73	请登录
PL03485-10mg	10mg	¥1854.55	请登录
PL03485-25mg	25mg	¥4080.00	请登录
PL03485-50mg	50mg	¥6429.09	请登录
PL03485-100mg	100mg	¥10261.82	请登录
PL03485-200mg	200mg	询价	询价
PL03485-500mg	500mg	询价	询价

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中文名称	Bendamustine
中文别名	宾达氮芥;苯达莫司汀;4-[5-[双(2-氯乙基)氨基]-1-甲基苯并咪唑-2-基]丁酸;苯达莫司汀标准品;宾达氮芥,苯达莫司汀;甲基1,2-环戊烯环氧物;盐酸苯达莫司汀
英文名称	Bendamustine
英文别名	4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid;5-(Bis(2-chloroethyl)amino)-1-methyl-2-benzimidazolebutyric acid;4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid;5-[bis(2-chloroethyl)amino]-1-methyl-1H-Benzimidazole-2-butanoic acid;Bendamustine;4-[5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl]butanoic acid;4-{5-[bis-(2-chloro-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acid;4-{5-[bis(2-chloroethyl)amino]-1-methyl-2-benzimidazolyl} butyric acid;4-<1-Methyl-5-benzimidazolyl-(2)>butansaeure;Bendamustin;Bendamustina [Spanish];Bendamustine (INN);BENDAMUSTINE ,USP;Bendamustinum [Latin];SDX 105;Treanda (TN);UNII-9266D9P3PQ;4-(5-(Bis(2-chloroethyl);1H-BenziMidazole-2-butanoicacid, 5-[bis(2-chloroethyl)aMino]-1-Methyl-
Cas No.	16506-27-7
分子式	C₁₆H₂₁N₃O₂Cl₂
分子量	358.26
包装储存	-20°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情

Bendamustine (SDX-105 free base)，一种嘌呤类似物，是一种 DNA 交联剂。Bendamustine 可激活 DNA 损伤反应和细胞凋亡 (apoptosis)。Bendamustine 具有有效的烷基化，抗癌和抗代谢作用。

生物活性

Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties.

性状

Solid

IC50 & Target[1][2]

DNA Alkylator/Crosslinker

体外研究(In Vitro)

Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties. Bendamustine uniquely regulates apoptosis pathways and DNA repair pathways in non-Hodgkins lymphoma cells. Bendamustine (50 μM) induces p21 (Cip1/Waf1) and NOXA genes, and increases the expression of p53 in SU-DHL-1 cells. Bendamustine (25 μM) blocks mitotic checkpoints and cuases mitotic catastrophe.
Bendamustine reduces the viability of multiple myeloma (MM) cell lines, such as RPMI-8226 and 8226-LR5 cells, with IC25s of 101.8 μM and 585.5 μM after 24 h incubation, and 51.7 and 374.3 μM after 48 h incubation, respectively. Bendamustine induces a specific caspase-dependent MM cell death and inhibits the spindle-assembly checkpoint. has not independently confirmed the accuracy of these methods

体内研究(In Vivo)

Bendamustine (25 mg/kg, i.v.) shows potent inhibition on the growth of tumor cells by 91%, 99% and 95% for DoHH-2, Granta 519 and RAMOS models, respectively. Moreover, the antitumor effect of Bendamustine is enhanced by rituximab in DoHH-2 and RAMOS models, but not in Granta 519 model. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

ClinicalTrial

参考文献

[1]. Leoni LM, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res. 2008 Jan 1;14(1):309-17.
[2]. Cives M, et al. Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe. Cell Signal. 2013 May;25(5):1108-17.

溶解度数据	In Vitro: DMSO : 100 mg/mL (279.13 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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