(S)-Verapamil hydrochloride|36622-28-3|((S)-(-)-Verapamil hydrochloride)-陌孚医药/Medlife

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(S)-Verapamil hydrochloride (Synonyms: (S)-(-)-Verapamil hydrochloride)

目录号: PL03456 纯度: ≥99%

CAS No. :36622-28-3

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中文名称	(S)-Verapamil hydrochloride
中文别名	S-维拉帕米;4-去氟-4-羟基吉非替尼;S(-)-维拉帕米
英文名称	(S)-Verapamil hydrochloride
英文别名	S(-)-VERAPAMIL;(S)-(-)-Verapamil Hydrochloride;(S)-(-)-Verapamil Hy;S(-)-VERAPAMIL HCL;S(−)-Verapamil hydrochloride hydrate;(S)-Verapamil hydrochloride
Cas No.	36622-28-3
分子式	C₂₆H₃₇N₂O₄+^.Cl-
分子量	477.04
包装储存	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

产品详情	(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) 通过 MRP1 抑制白三烯 C4 (LTC4) 和钙黄绿素的转运。(S)-Verapamil hydrochloride 导致潜在耐药性肿瘤细胞死亡。
生物活性	(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells.
性状	Solid
IC50 & Target[1][2]	LTC4
体外研究(In Vitro)	(S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) not the (R)-Verapamil hydrochloride potently induces the death of MRP1-transfected BHK-21 cells. (S)-Verapamil hydrochloride is good active form and has the low bioavailability. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, stored under nitrogen In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献	[1]. Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22. [2]. Tannergren C, et al. St Johns wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75(4):298-309.

溶解度数据	In Vitro: DMSO : 200 mg/mL (407.28 mM; Need ultrasonic)H₂O : 100 mg/mL (203.64 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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