Arzoxifene hydrochloride|182133-27-3|(LY353381 hydrochloride; SERM III hydrochloride)-陌孚医药/Medlife

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Arzoxifene hydrochloride (Synonyms: LY353381 hydrochloride; SERM III hydrochloride)

目录号: PL03475 纯度: ≥98%

CAS No. :182133-27-3

商品编号	规格	价格	会员价
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PL03475-10mg	10mg	¥17803.64	请登录
PL03475-50mg	50mg	询价	询价
PL03475-100mg	100mg	询价	询价

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中文名称	Arzoxifene hydrochloride
中文别名	阿佐昔芬盐酸盐
英文名称	Arzoxifene hydrochloride
英文别名	Benzo[b]thiophene-6-ol,2-(4-methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-, hydrochloride(1:1);2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol,hydrochloride;Benzo[b]thiophene-6-ol,2-(4-methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-, hydrochlor...;Arzoxifene HCl;Arzoxifene hydrochloride;SERM 3;LY 353381 HCl;Ly 353381;NHSNLUIMAQQXGR-UHFFFAOYSA-N;2-(p-Methoxyphenyl)-3-(p-(2-(1-piperidinyl)ethoxy)phenoxy)benzo(B)thiophene-6-ol hydrochloride;2-(4-Methoxyphenyl)-3-(4-(2-(1-piperidinyl)ethoxy)phenoxy)benzo(B)thiophene-6-ol hydrochloride;Benzo(B)thiophene-6-ol, 2-(4-methoxyphenyl)-3-(4-(2-(1-piperidinyl)ethoxy)phenoxy)-, hydrochloride
Cas No.	182133-27-3
分子式	C₂₈H₂₉NO₄S^.HCl
分子量	512.06
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Arzoxifene (LY353381) hydrocloride 是一种选择性的雌激素受体 (estrogen receptor) 调节剂，它是乳腺和子宫组织中有效的雌激素拮抗剂，同时作为维持骨密度和降低血清胆固醇的雌激素激动剂。

生物活性

Arzoxifene (LY353381) hydrocloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol.

性状

Solid

IC50 & Target[1][2]

Estrogen receptor

体外研究(In Vitro)

Arzoxifene inhibits cell growth as effectively as the antiestrogen tamoxifen. Northern analysis reveals that arzoxifene exerts a statistically significant inhibition of pS2 and progesterone receptor B mRNA expression. Significant agonistic effect is observed on the antitrypsin mRNA expression. In contrast to estradiol and tamoxifen, arzoxifene does not upregulate cathepsin D mRNA and protein expression. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Arzoxifene prevents the ovariectomy-induced increase in body weight and serum cholesterol levels of treated rats and lowers them to below sham levels in a dose dependent manner, with maximum efficacy similar to estrogen or raloxifene. Arzoxifene (LY353381.HCl) prevents loss of bone due to ovariectomy with an ED 50 of about 0.01 mg/kg with maximal efficacy observed at 0.1-1 mg/kg/day. Arzoxifene (LY353381.HCl) antagonizes the estrogen-induced elevation in uterine weight down to vehicle-dosed control levels with ED 50 of 0.03 mg/kg/day. has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Suh N, et al. Arzoxifene, a new selective estrogen receptor modulator for chemoprevention of experimental breast cancer. Cancer Res. 2001 Dec 1;61(23):8412-5.

溶解度数据	In Vitro: DMSO : 25 mg/mL (48.82 mM; ultrasonic and warming and heat to 60°C)配制储备液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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