ADRA1D receptor antagonist 1|1191908-14-1|-陌孚医药/Medlife

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ADRA1D receptor antagonist 1

目录号: PL03447 纯度: ≥98%

CAS No. :1191908-14-1

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中文名称	ADRA1D receptor antagonist 1
英文名称	ADRA1D receptor antagonist 1
英文别名	ADRA1D receptor antagonist 1
Cas No.	1191908-14-1
包装储存	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

产品详情	ADRA1D receptor antagonist 1 是一个高效、选择性的，有口服活性的 α_1D 肾上腺素受拮抗剂，K_i 值为 1.6 nM。
生物活性	ADRA1D receptor antagonist 1 is a potent, selective and orally active α 1D adrenoceptor antagonist, with a K i of 1.6 nM.
性状	Solid
IC50 & Target[1][2]	Ki: 1.6 nM (α1D adrenoceptor)
体外研究(In Vitro)	ADRA1D receptor antagonist 1 shows low hERG inhibition. ADRA1D receptor antagonist 1 exhibits higher selectivity for α1D-AR over α1A- and α1B-ARs . has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	ADRA1D receptor antagonist 1 (4.4 μg/kg; i.v.) dose-dependently decreases the non-voiding bladder contractions during the urinary storage phase in rats with BOO. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献	[1]. Sakauchi N, et al. Discovery of 5-Chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide (TAK-259) as a Novel, Selective, and Orally Active α1D Adrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human Ethe

溶解度数据	In Vitro: DMSO : 100 mg/mL (296.56 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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