(Rac)-Indoximod|26988-72-7|((Rac)-1-甲基-D-色氨酸; 1-Methyl-DL-tryptophan; (Rac)-NLG-8189)-陌孚医药/Medlife

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(Rac)-Indoximod (Synonyms: (Rac)-1-甲基-D-色氨酸; 1-Methyl-DL-tryptophan; (Rac)-NLG-8189)

目录号: PL03384 纯度: ≥98%

CAS No. :26988-72-7

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中文名称	(Rac)-Indoximod
中文别名	1-甲基-DL-色氨酸;1-甲基-色氨酸
英文名称	(Rac)-Indoximod
英文别名	2-Amino-3-(1-methyl-1H-indol-3-yl)propanoic acid;1-Methyl-DL-tryptophan;2-amino-3-(1-methylindol-3-yl)propanoic acid;1-methyl-(D,L)-tryptophan;1-Methyltryptophan;1-Methyl-tryptophan;1-MT;2-amino-3-(1-methyl-1H-indol-3-yl)-propanoic acid;AG-E-85660;CHEBI:72821;DL-1-Methyltryptophan;L-Tryptophan, 1-methyl-;methyl tryptophan;racemic N-methyl tryptophan;racemic-1-methyl-D-tryptophan;(Rac)-Indoximod
Cas No.	26988-72-7
分子式	C₁₂H₁₄N₂O₂
分子量	218.25
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	(Rac)-Indoximod (1-Methyl-DL-tryptophan) 是吲哚胺-2,3-双加氧酶 (IDO) 抑制剂。(Rac)-Indoximod 和 IFN-γ 联用显著降低了表达 α-SMA 的人心肌成纤维细胞活性，并通过上调 IRF-1，Fas 和 FasL 基因诱导凋亡(apoptosis)。
生物活性	(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes.
性状	Solid
IC50 & Target[1][2]	IDO
体外研究(In Vitro)	(Rac)-Indoximod (1-Methyl-DL-tryptophan; 0.5 mM; 3 days) inhibits tryptophan depletion, thereby partially reversing the growth-inhibitory activity of IFN-γ, but eventually induces cell death regardless of tryptophan depletion. has not independently confirmed the accuracy of these methods. They are for reference only.Cell Viability Assay-tbl">
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Jun-Won Lee,et al. Co-treatment with interferon-γ and 1-methyl tryptophan ameliorates cardiac fibrosis through cardiac myofibroblasts apoptosis. Mol Cell Biochem. 2019 Aug;458(1-2):197-205.

溶解度数据	In Vitro: 0.1 M NaOH : 10 mg/mL (45.82 mM; Need ultrasonic)DMSO : 4.76 mg/mL (21.81 mM; ultrasonic and warming and adjust pH to 4 with HCl and heat to 60°C)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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