1,1,3-Tribromoacetone 是甲氨蝶呤 (HY-14519) 的杂质。Methotrexate (Amethopterin) 是一种抗代谢 (antimetabolite) 和抗叶酸剂 (antifolate)，可抑制二氢叶酸还原酶，从而防止叶酸转化为四氢叶酸并抑制 DNA 合成。

1,1,3-Tribromoacetone is an impurity of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.

Liquid

Methotrexate (Amethopterin) reduces thymus and spleen indices of mice. Methotrexate markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice.
Methotrexate (MTX) (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freunds complete adjuvant-induced arthritis. The combination of Methotrexate (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity.

Room temperature in continental US; may vary elsewhere.

Pure form -20°C 3 years；In solvent -80°C 6 months

[1]. Balwant Singh, et al. Process for the preparation of high purity methotrexate and derivatives thereof. Patent US4374987A 87A
[2]. [2].Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92
[3]. Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freunds complete adjuvant-induced a

In Vitro: DMSO : 100 mg/mL (339.25 mM; Need ultrasonic)配制储备液