3-Hydroxy agomelatine|166526-99-4|-陌孚医药/Medlife

您当前的位置：

3-Hydroxy agomelatine

目录号: PL03338 纯度: ≥98%

CAS No. :166526-99-4

商品编号	规格	价格	会员价
PL03338-5mg	5mg	¥5934.55	请登录
PL03338-10mg	10mg	询价	询价
PL03338-50mg	50mg	询价	询价
PL03338-10mM*1mLinDMSO	10mM*1mLinDMSO	¥6528.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	3-Hydroxy agomelatine
中文别名	3-羟基阿戈美拉汀;3-羟基阿戈美拉汀代谢物;阿戈美拉汀杂质对照品
英文名称	3-Hydroxy agomelatine
英文别名	3-Hydroxyagomelatine ;3-Hydroxyagomelatine;3-Hydroxy agomelatine
Cas No.	166526-99-4
分子式	C₁₅H₁₇NO₃
分子量	259.30
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	3-Hydroxy agomelatine 是 Agomelatine 的代谢产物。3-Hydroxy agomelatine 是 5-HT_2C 受体拮抗剂，IC₅₀ 为 3.2 μM，K_i 为 1.8 μM。
生物活性	3-Hydroxy agomelatine is a metabolite of Agomelatine. 3-Hydroxy agomelatine is a 5-HT 2C receptor antagonist with an IC 50 of 3.2 μM and a K i of 1.8 μM.
性状	Solid
IC50 & Target[1][2]	5-HT2C Receptor 3.2 μM (IC50) 5-HT2C Receptor
体外研究(In Vitro)	Agomelatine and S 21517 have moderately high affinities for 5-HT2C receptors (Ki = 0.21 μM and 0.13 μM, respectively). The metabolite 3-Hydroxy agomelatine (S 21540) has a 10-fold lower affinity (Ki = 1.8 μM). Agomelatine, S 21517 and 3-Hydroxy agomelatine (10-10 M) are antagonists at 5-HT2C receptors, with a rank order of efficacy as follows: S 21517>Agomelatine>3-Hydroxy agomelatine. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Increasing doses (from 1.25 to 40 mg/kg, intraperitoneal injection) of 3-Hydroxy agomelatine (S 21540) does not affect the penile erections induced by mCPP and Ro 60-0175 in Wistar rat. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Chagraoui A, et al. Agomelatine(S 20098) antagonizes the penile erections induced by the stimulation of 5-HT2C receptors in Wistar rats. Psychopharmacology (Berl). 2003 Oct;170(1):17-22.

溶解度数据	In Vitro: DMSO : 250 mg/mL (964.13 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation