TAME hydrochloride|1784-03-8|-陌孚医药/Medlife

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TAME hydrochloride

目录号: PL03302 纯度: ≥98%

CAS No. :1784-03-8

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中文名称	TAME hydrochloride
中文别名	N-对甲苯磺酰基-L-精氨酸甲酯盐酸盐;Nα-对甲苯磺酰基-L-精氨酸甲酯盐酸盐;Nalpha-Tosyl-L-arginine Methyl Ester Hydrochloride Nα-对甲苯磺酰基-L-精氨酸甲酯盐酸盐;NA-P-甲苯磺基-L-精氨酸甲酯盐酸盐;NA-P-甲苯磺酰-L-精氨酸甲酯盐酸盐;Na-对甲苯磺酰-L-精氨酸甲酯盐酸盐;Nα-对甲苯磺酰-L-精氨酸甲酯盐酸盐（TAME）;N-对***磺酰基-L-精氨酸甲酯盐酸盐;N-对甲苯磺酰-L-精氨酸甲酯盐酸盐;4,5-羟基萘乙烯;NA-P-甲苯磺基...;Nα-p-甲苯磺酰基-L-精氨酸甲酯盐酸盐;N-Α-甲苯磺酰-L-精氨酸甲酯盐酸盐;N-Α-甲苯磺酰精氨酸甲酯盐酸盐;TAME盐酸盐
英文名称	TAME hydrochloride
英文别名	(S)-Methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate hydrochloride;Methyl N-[(p-tolyl)sulphonyl]-L-argininate monohydrochloride;Nalpha-Tosyl-L-arginine Methyl Ester Hydrochloride;Nα-P-Tosyl-L-arginine methyl ester hydrochloride;(S)-Methyl 5-guanidino-2-(4-methylphenylsulfonamido)-pentanoate hydrochloride;Bz-Arg-Ome.HCl;methyl (2S)-5-(diaminomethylideneamino)-2-[(4-methylphenyl)sulfonylamino]pentanoate,hydrochloride;N-4-Tosyl-L-arginine Methyl Ester Hydrochloride;N-a-p-Tosyl-L-argininemethylesterhydrochloride;P-TOSYL-L-ARG METHYL ESTER HCL;TAME HCL;TAME hydrochloride;Tos-Arg-OMe · HCl;TOS-ARG-OME HCL;Tos-Arg-OMe.HCl;Tos-Arg-OMe•HCl;Nalpha-4-Tosyl-L-arginine Methyl ester hydrochloride;Nalpha-p-Toluenesulfonyl-L-Arginine Methyl Ester Hydrochloride;Nα-p-Toluenesulfonyl-L-arginine Methyl Ester Hydrochloride;Nα-p-Tosyl-L-arginine methyl;N-α-Tosyl-L-arginine methyl ester hydrochloride;Nα-Tosyl-L-arginine Methyl Ester Hydrochloride;Tos-Arg-OMe·HCl;TAME;L-TAME;Nalpha-p-Tosyl-L-arginine methyl ester hydrochloride;Tos-Arg-OMeHCl;n-p-tosyl-l-arginine methyl ester hydrochloride;TOS-ARG-OME hydrochloride;tos-arg-ome-hcl;JIQFFACVQXXHMY-YDALLXLXSA;TAME Hydrochloride
Cas No.	1784-03-8
分子式	C₁₄H₂₃ClN₄O₄S
分子量	378.87
包装储存	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	TAME hydrochloride 是后期促进复合体 (APC/C 或 APC) 的抑制剂，它与 APC/C 结合并阻止其通过 Cdc20 和 Cdh1 活化，产生有丝分裂阻滞。TAME hydrochloride 不能透过细胞膜。
生物活性	TAME hydrochloride is an inhibitor of anaphase-promoting complex/cyclosome (APC/C or APC), which binds to APC/C and prevents its activation by Cdc20 and Cdh1, produces mitotic arrest. TAME hydrochloride is not cell permeable.
性状	Solid
IC50 & Target[1][2]	Anaphase-promoting complex (APC)
体外研究(In Vitro)	The absence of APC substrates, TAME hydrochloride ejects Cdc20 from the APC by promoting Cdc20 auto-ubiquitination in its N-terminal region. Cyclin B1 antagonizes TAME hydrochlorides effect by promoting binding of free Cdc20 to the APC and suppressing Cdc20 auto-ubiquitination. TAME hydrochloride stabilizes cyclin B1 in Xenopus extract by two mechanisms. First, it reduces the kcat of the APC/cyclin B1 complex without affecting the Km, slowing the initial ubiquitination of unmodified cyclin B1. Second, as cyclin B1 becomes ubiquitinated, it loses its ability to promote Cdc20 binding to the APC in the presence of TAME hydrochloride. As a result, cyclin B1 ubiquitination terminates before reaching the threshold necessary for proteolysis. has not independently confirmed the accuracy of thes
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Zeng X, et al. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 2010 Oct 19;18(4):382-95. [2]. Zeng X, et al. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nat Chem Biol. 2012 Feb 26;8(4):383-92.

溶解度数据	In Vitro: DMSO : 155 mg/mL (409.11 mM; Need ultrasonic)H₂O : ≥ 100 mg/mL (263.94 mM)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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