CHIKV-IN-2|2361289-44-1|-陌孚医药/Medlife

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CHIKV-IN-2

目录号: PL03269 纯度: ≥98%

CAS No. :2361289-44-1

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中文名称	CHIKV-IN-2
英文名称	CHIKV-IN-2
英文别名	CHIKV-IN-2
Cas No.	2361289-44-1
分子式	C₂₃H₂₆N₂O₂
分子量	362.46
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情	CHIKV-IN-2 是一种针对基孔肯雅病毒 (CHIKV) 的有效抑制剂，具有出色的细胞抗病毒活性 (EC₉₀=270 nM) 和改善的肝微粒体稳定性。CHIKV-IN-2 对细胞靶二氢乳清酸脱氢酶 (DHODH) 表现出抑制活性。
生物活性	CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV), with excellent cellular antiviral activity (EC 90 =270 nM) and improved liver microsomal stability. CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH), which interacts with various viruses and regulate their replication via depleting intracellular pyrimidine pools.
性状	Solid
IC50 & Target[1][2]	EC90: 270 nM (Chikungunya virus) Dihydroorotate Dehydrogenase
体外研究(In Vitro)	CHIKV-IN-2 (compound 8q) is a potent pan-alphavirus inhibitor, with EC90s of 0.85-2.5 μM for CHIKV clinical isolates and attenuated vaccine strains. CHIKV-IN-2 is active against alphavirus VEEV (EC90=0.40 μM) as well as flaviviruses such as West Nile Virus (WNV, EC90=0.20 μM) and Dengue Virus Strain-2 (DENV-2, EC90=0.60 μM). has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	CHIKV-IN-2 (compound 8q) (80 mg/kg; i.p. twice a day for 3 days) significantly decreases infectious CHIKV dissemination to other tissues of mice. CHIKV-IN-2 (40 mg/kg; p.o., i.p., s.c.) exhibits moderate bioavailability (F=41%, 43%, 4%), terminal elimination half-life (t 1/2 =9.9, 18.5, 18.6 h) and C max (642, 858, 90 ng/mL) in mice. CHIKV-IN-2 (1 mg/kg; i.v.) exhibits terminal elimination half-life (t 1/2 = 2.02 h) and AUC (497 h?ng/mL) in mice. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；In solvent -80°C 6 months
参考文献	[1]. Ahmed SK, et, al. Targeting Chikungunya Virus Replication by Benzoannulene Inhibitors. J Med Chem. 2021 Apr 22;64(8):4762-4786.

溶解度数据	In Vitro: DMSO : 100 mg/mL (275.89 mM; Need ultrasonic)配制储备液

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