EBNA1-IN-SC7
目录号: PL03213 纯度: ≥95%
CAS No. :324022-08-4
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中文名称
EBNA1-IN-SC7
中文别名
化合物 EBNA1-IN-SC7
英文名称
EBNA1-IN-SC7
英文别名
SR-01000400015-1;SMR000554651;MS-28487;Oprea1_403629;SR-01000400015;CHEMBL1377533;324022-08-4;MLS001194820;CS-0131431;2-BROMO-4-[N-(NAPHTHALENE-2-SULFONYL)ACETAMIDO]PHENYL ACETATE;HMS2868E03;AG-690/36423053;AKOS001484745;[4-[acetyl(naphthalen-2-ylsulfonyl)amino]-2-bromophenyl] acetate;EBNA1-IN-SC7;4-[acetyl(2-naphthylsulfonyl)amino]-2-bromophenyl acetate;HY-131236;Oprea1_235208;EU-0068103;MFCD00567864
Cas No.
324022-08-4
分子式
C20H16BrNO5S
分子量
462.31
包装储存
Powder -20°C 3 years;4°C 2 years
产品详情
EBNA1-IN-SC7 (compound SC7) 是一种选择性 Epstein-Barr nuclear antigen 1 (EBNA1) 抑制剂,可干扰 EBNA1-DNA 结合活性,其 IC50 值为 23 μM。EBNA1-IN-SC7 可用于 EBV (Epstein-Barr virus) 相关癌症研究。
生物活性
EBNA1-IN-SC7 (compound SC7) is a selective Epstein-Barr nuclear antigen 1 (EBNA1) inhibitor that interferes with EBNA1-DNA binding activity with an IC 50 value of 23 μM. EBNA1-IN-SC7 is used in EBV (Epstein-Barr virus)-related cancer research.
性状
Solid
体外研究(In Vitro)
EBNA1-IN-SC7 (compound SC7) (5 μM) can completely block transcriptional activation of EBNA1 and show a 60% inhibition of Zta (EBV-encoded b-zip DNA binding protein) trans-activation in HEK293T cells.
EBNA1-IN-SC7 (compound SC7) (10 μM, 6 days) has no significant effect on EBV genome copy number of Raji Burkitt lymphoma cells.
has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
参考文献
[1]. Lijun Jiang, et al. EBNA1-targeted inhibitors: Novel approaches for the treatment of Epstein-Barr virus-associated cancers. Theranostics. 2018 Oct 22;8(19):5307-5319.
[2]. Ning Li, et al. Discovery of selective inhibitors against EBNA1 via high throughput in silico virtual screening. PLoS One. 2010 Apr 12;5(4):e10126.
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