FKBP12 PROTAC RC32 (RC32) 是基于 PROTAC 的有效 FKBP12 降解剂。FKBP12 PROTAC RC32 包含雷帕霉素 (Rapamycin；HY-10219) 和Cereblon E3 泛素连接酶配体 (Pomalidomide；HY-10984)。

FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology. FKBP12 PROTAC RC32 contains conjugation of Rapamycin (HY-10219) and a ligand for an Cereblon E3 ubiquitin ligase (Pomalidomide; HY-10984).

Solid

Cereblon

FKBP12 PROTAC RC32 (RC32; 0.1-1000 nM; for 12?hours) results in 50% protein degradation (DC50) of ~0.3?nM after only 12?hours of treatment.
has not independently confirmed the accuracy of these methods. They are for reference only.Western Blot Analysis

RC32 (RC32; i.p.; 30?mg/kg; twice a day; 1 day) degrades the FKBP12 protein in most of the organs of treated mice, except for the brain after only 1 day of treatment in mice.
RC32 (orally; 60?mg/kg; twice a day; for 1 day) significantly degrades FKBP12 in mice.
RC32 (i.p.; 8?mg/kg; twice a day; for 2 days) efficiently degrades the FKBP12 protein in most of the organs examined in Bama pigs (20?kg) .
RC32 (i.p.; 8?mg/kg; twice a day; for 3 days) efficiently degrades FKBP12 in the heart, liver, kidney, spleen, lung, and stomach of rhesus monkeys.
has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. A chemical approach for global protein knockdown from mice to non-human primates. Cell Discov. 2019 Feb 5;5:10.

In Vitro: DMSO : 10 mg/mL (7.01 mM; Need ultrasonic)配制储备液