Stearoyl-L-carnitine chloride|32350-57-5|-陌孚医药/Medlife

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Stearoyl-L-carnitine chloride

目录号: PL03139 纯度: ≥98%

CAS No. :32350-57-5

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中文名称	Stearoyl-L-carnitine chloride
中文别名	硬脂酰肉碱
英文名称	Stearoyl-L-carnitine chloride
英文别名	R-Stearoyl Carnitine Chloride;STEAROYL-L-CARNITINE CHLORIDE;[(2R)-3-Carboxy-2-octadecanoyloxypropyl]-trimethylazanium;chloride
Cas No.	32350-57-5
分子式	C₂₅H₅₀ClNO₄
分子量	464.12
包装储存	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Stearoyl-L-carnitine chloride 是一种内源性的长链酰基肉碱。Stearoyl-L-carnitine chloride 是一种效力较弱的 GlyT2 抑制剂。Stearoyl-L-carnitine chloride 在浓度高达 3 μM 时可抑制 16.8％的甘氨酸响应。
生物活性	Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2. Stearoyl-L-carnitine chloride inhibits glycine responses by 16.8% at concentrations up 3 μM.
性状	Solid
IC50 & Target[1][2]	GlyT2
体外研究(In Vitro)	Stearoyl-L-carnitine (0.01-10 μM) inhibits glycine (30 μM) transports by 16.8% at concentrations up 3 μM in Xenopus laevis oocytes. Stearoyl-L-carnitine (500 μM; 30 min) inhibits Na-dependent [H]carnitine (20 nM) uptake by ~50% in HPCT cells. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Stearoyl-L-carnitine is significantly decreased in Alzheimers disease (AD), mild cognitive impairment (MCI) and subjective memory complaint (SMC). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Cristofano A, et, al. Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimers Dementia. PLoS One. 2016 May 19;11(5):e0155694. [2]. Carland JE, et, al. Oleoyl-L-carnitine inhibits glycine transport by GlyT2. Br J Pharmacol. 2013 Feb;168(4):891-902. [3]. Huang W, et, al. Carnitine transport

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