Thiodigalactoside|51555-87-4|(TDG)-陌孚医药/Medlife

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Thiodigalactoside (Synonyms: TDG)

目录号: PL03113 纯度: ≥99%

CAS No. :51555-87-4

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中文名称	Thiodigalactoside
中文别名	D-吡喃半乳糖 β-D-硫代吡喃半乳糖苷;硫代二半乳糖苷;硫代半乳糖苷
英文名称	Thiodigalactoside
英文别名	THIODIGALACTOSIDE;D-GALACTOPYRANOSYL-B-D-THIOGALACTOPYRANOSIDE;β-D-Galactopyranosyl 1-thio-β-D-galactopyranoside;D-Galactopyranosyl-β-D-thiogalactopyranoside;D-Galactopyranosylthio-β-D-galactopyranoside;TDG
Cas No.	51555-87-4
分子式	C₁₂H₂₂O₁₀S
分子量	358.36
包装储存	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	Thiodigalactoside (TDG) 是一种具有口服活性的，有效的半乳凝素 (GAL) 抑制剂，对于 GAL-1 和 GAL-3 的 K_d 值分别为 24 μM，49 μM。Thiodigalactoside 是一种不可代谢的二糖，具有抗炎和抗癌活性。Thiodigalactoside 可显着降低饮食诱发的肥胖大鼠的体重增加。
生物活性	Thiodigalactoside (TDG) is an orally active and potent galectin (GAL) inhibitor with K d values of 24 μM, 49 μM for GAL1 and GAL3, respectively. Thiodigalactoside, a non-metabolizable disaccharide, has anti-inflammatory and anti-cancer activity. Thiodigalactoside dramatically reduces body weight gain in diet-induced obese rats.
性状	Solid
IC50 & Target[1][2]	Kd: 24 μM (GAL1) and 49 μM (GAL3)
体外研究(In Vitro)	Thiodigalactoside (TDG; 250 and 500?μM) exhibits dose-dependent reduction of fat accumulation based on triglyceride (TG) content and Oil Red O (ORO) staining. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Thiodigalactoside (TDG; 5?mg/kg; IP; once per week for 5 weeks) results in dramatic inhibition of HFD-induced body weight gain. Thiodigalactoside (5?mg/kg; oral; daily or weekly for 5 weeks) gave less reduction in body weight gain compare with i.p.. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	-20°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Hilde van Hattum, et al. Tuning the Preference of Thiodigalactoside- And Lactosamine-Based Ligands to galectin-3 Over galectin-1. J Med Chem. 2013 Feb 14;56(3):1350-4. [2]. Varun V Prabhu, et al. Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner. Cancer Res. 2015 Apr 1;75(7):1423-32.

溶解度数据	In Vitro: H₂O : 100 mg/mL (279.05 mM; Need ultrasonic)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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