5-Hydroxymethyl-2'-deoxyuridine|5116-24-5|-陌孚医药/Medlife

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5-Hydroxymethyl-2'-deoxyuridine

目录号: PL03086 纯度: ≥99%

CAS No. :5116-24-5

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中文名称	5-Hydroxymethyl-2'-deoxyuridine
中文别名	2 -脱氧-5-羟甲基尿甙;2''-脱氧-5-羟甲基尿甙;2'-脱氧-5-羟甲基尿甙;5-羟基甲基-2-脱氧尿苷;5-羟甲基脱氧尿苷;5-羟甲基尿嘧啶脱氧核苷
英文名称	5-Hydroxymethyl-2'-deoxyuridine
英文别名	5-Hydroxymethyl-2'-deoxyuridine;5-Hydroxymethyl-2’-deoxyuridine;Thymidine, a-hydroxy-;5-HMdU HMdUdr
Cas No.	5116-24-5
分子式	C₁₀H₁₄N₂O₆
分子量	258.23
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	5-Hydroxymethyl-2'-deoxyuridine 是核苷类似物。5-Hydroxymethyl-2'-deoxyuridine 抑制多种人类白血病细胞系的复制 IC₅₀ 值为 1.7-5.8 μM。5-Hydroxymethyl-2'-deoxyuridine 延长了携带 L1210 白血病的小鼠的存活时间。5-Hydroxymethyl-2'-deoxyuridine 可用于细胞复制和白血病的研究。
生物活性	5-Hydroxymethyl-2-deoxyuridine is a nucleoside analog. 5-Hydroxymethyl-2-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC 50 values of 1.7-5.8 μM. 5-Hydroxymethyl-2-deoxyuridine prolongs the survival of mice carrying L1210 leukemia. 5-Hydroxymethyl-2-deoxyuridine can be used for the research of cell replication and leukemia.
性状	Solid
体外研究(In Vitro)	5-Hydroxymethyl-2-deoxyuridine (0-10 μM) inhibits the replication of Sarcoma 180 cells and Ehrlich ascites carcinoma cells with ED50 values of 8.5 and 4 μM, respectively. 5-Hydroxymethyl-2-deoxyuridine inhibits herpes simplex virus type 1 (HSV-1) pyrimidine 2’-deoxyribonucleoside kinase with a Ki value of 3.5 μM. 5-Hydroxymethyl-2-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC50 values of 1.7-5.8 μM. 5-Hydroxymethyl-2-deoxyuridine (10-100 μM) shows dose-dependent toxicity against a human acute promyelocytic leukemia cell line. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	5-Hydroxymethyl-2-deoxyuridine (0, 5 and 50 mg/kg; i.p.; once) increases the survival of DBA/2 mice carrying L1210 leukemia. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Shiau GT, et al. Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2-deoxyuridine and related 5-substituted analogues. J Med Chem. 1980 Feb;23(2):127-33. [2]. Kahilainen LI, et al. 5-Hydroxymethyl-2-deoxyuridine. Cytotoxicity and DNA incorporation studied by using a novel [2-14C]-derivative with normal and leukemic human hematopoietic cells. Acta Chem Scand B. 1985;39(6):477-84.

溶解度数据	In Vitro: DMSO : ≥ 125 mg/mL (484.06 mM)配制储备液

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