Bromelain
目录号: PL03068 纯度: ≥300u/mg
CAS No. :9001-00-7
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中文名称
Bromelain
中文别名
菠萝蛋白酶;菠萝酶;菠罗蛋白酶;风梨酶;菠萝朊酶;波萝蛋白酶
英文名称
Bromelain
英文别名
Bromelains;STEM BROMELAIN;BROMELAIN;BROMELAIN PINEAPPLE;BROMELIN;Brome laine;BROMELAIN(RG);Bromelein;Bromelain, pure;BroMelain, pure, 1200 GDU,g;FROM PINEAPPLE, 2400GDU;Technical Grade;Bromelain, juice (9CI);Fruit bromelain (ACI);Ananase;Ananases;Bromelain;Bromelase;Bromelases;Bromelin;Bromelins;Debridase;Debridases;E.C. 3.4.22.33;E.C. 3.4.22.5;EC 3.4.22.33;EC 3.4.22.5;Extranase;Extranases;Inflamen;Juice bromelain;Pinase;Pinases;Pineapple enzyme;Pineapple enzymes;Traumanase;Traumanases
Cas No.
9001-00-7
包装储存
Powder -20°C 3 years;4°C 2 years
产品详情
Bromelain 是一种源自菠萝茎的抗炎药,其通过下调血浆激肽原,抑制前列腺素 E2 表达,降解晚期糖基化终产物受体,调节血管生成生物标志物以及在 COX 途径上游发生抗氧化作用而发挥作用。Bromelain 具有多种纤维蛋白溶解,抗水肿,抗血栓形成和抗炎活性。Bromelain 还具有一些抗癌活性,并促进凋亡细胞死亡。
生物活性
Bromelain is an anti-inflammatory drug derived from pineapple stem that acts through down-regulation of plasma kininogen, inhibition of Prostaglandin E2 expression, degradation of advanced glycation end product receptors and regulation of angiogenic biomarkers as well as antioxidant action upstream in the COX-pathway. Bromelain exhibits various fibrinolytic, antiedematous, antithrombotic, and anti-inflammatory activities. Bromelain also possesses some anticancerous activities and promotes apoptotic cell death.
性状
Solid
体内研究(In Vivo)
Bromelain (40 mg/kg; intraperitoneal injection; daily; for 7 days; male Sprague-Dawley rats) pretreatment reduces the motor dysfunction in the parkinsonian rat model of parkinsons disease (PD). 6-OHDA injection resulted in marked motor impairment which is prevented by pretreatment with Bromelain prior to the lesion. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
ClinicalTrial
参考文献
[1]. Adu TS, et al. Effects of bromelain on motor responses following intra-medial forebrain bundle 6-OHDA injection in rat model of parkinsonism. Metab Brain Dis. 2019 Jul 22.
[2]. Pavan R, et al. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int. 2012;2012:976203.
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2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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