BPAM344|1204572-55-3|-陌孚医药/Medlife

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BPAM344

目录号: PL03023 纯度: ≥98%

CAS No. :1204572-55-3

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中文名称	BPAM344
英文名称	BPAM344
英文别名	4-Cyclopropyl-7-Fluoro-3,4-Dihydro-2h-1,2,4-Benzothiadiazine 1,1-Dioxide;2J9;BPAM344;TQR0610;4n07;BDBM50032241;BPAM344, >=98% (HPLC);Q27453039;3,4-Dihydro-4-cyclopropyl-7-fluoro-2H-1,2,4-benzothiadiazine 1,1-dioxide;4-cyclopropyl-7-fluoro-2,3-dihydro-1$l^{6},2,4-benzothiadiazine 1,1-dioxide;4-cyclopropyl-7-fluoro-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide;4-Cyclopropyl-3,4-dihydro-7-fluoro-2H-1,2,4-benzothiadiazine 1,1-dioxide;4-Cyclopropyl-3,4-dihydro-7-fluoro-2H-1,2,4-benzothiadiazine 1,1-dioxide;4-Cyclopropyl-3,4-dihydro-7-fluoro-2H-1,2,4-benzothiadiazine 1,1-dioxide
Cas No.	1204572-55-3
分子式	C₁₀H₁₁FN₂O₂S
分子量	242.27
包装储存	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	BPAM344 是红藻氨酸受体 (KAR) 亚基 GluK1b、GluK2a 和 GluK3a 的正变构调节剂 (PAM)。
生物活性	BPAM344 is a kainate receptor (KAR) subunits GluK1b, GluK2a, and GluK3a positive allosteric modulator (PAM).
性状	Solid
体外研究(In Vitro)	BPAM344 potentiates glutamate-evoked currents of GluK2a 21-fold at the highest concentration tested (200 μM), with an EC50 of 79 μM. BPAM344 markedly decreases desensitization kinetics (from 5.5 to 775 ms), whereas it only has a minor effect on deactivation kinetics. BPAM344 (100 μM) also potentiates the peak current amplitude of KAR subunits GluK3a (59-fold), GluK2a (15-fold), GluK1b (5-fold), as well as the AMPA receptor subunit GluA1i (5-fold). has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	[1]. Anja Probst Larsen, et al. Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors. Mol Pharmacol. 2017 Jun;91(6):576-585.

溶解度数据	In Vitro: DMSO : 250 mg/mL (1031.91 mM; Need ultrasonic)配制储备液

搜索质检报告(COA)

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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