UC-112|383392-66-3|-陌孚医药/Medlife

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UC-112

目录号: PL02934 纯度: ≥99%

CAS No. :383392-66-3

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中文名称	UC-112
中文别名	5-[(苯基甲氧基)甲基]-7-(1-吡咯烷基甲基)-8-喹啉醇;凋亡抑制蛋白IAP抑制剂(UC-112);化合物 T17195
英文名称	UC-112
英文别名	UC 112;UC-112;MLS002276469;5-((benzyloxy)methyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol;SMR001318010;5-[(Phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol;5-(phenylmethoxymethyl)-7-(1-pyrrolidinylmethyl)-8-quinolinol;5-((Benzyloxy)methyl)-7-(1-pyrrolidinylmethyl)-8-quinolinol;5-[(Benzyloxy)methyl]-7-(1-pyrrolidinylmethyl)-8-quinolinol;5-(phenylmethoxymethyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol;Oprea1_608159;HMS2221;CS-2116;8-Quinolinol, 5-[(phenylmethoxy)methyl]-7-(1-pyrrolidinylmethyl)-
Cas No.	383392-66-3
分子式	C₂₂H₂₄N₂O₂
分子量	348.44
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	UC-112是凋亡抑制蛋白IAP新型高效抑制剂，癌细胞IC50值0.7-3.4uM。
生物活性	UC-112 is a novel potent IAP(Inhibitor of apoptosis) inhibitor; potently inhibit cell growth in two human melanoma (A375 and M14) and two human prostate (PC-3 and DU145) cancer cell lines(IC50=0.7-3.4 uM). IC50 value: 0.7-3.4 uM (Cell assay) [1] Target: IAP inhibitor in vitro: UC-112 also potently inhibits the growth of P-glycoprotein (P-gp)-overexpressed multidrug-resistant cancer cells, strongly activates caspase-3/7 and caspase-9 activities, and selectively downregulates survivin level at a concentration as low as 1 μM. Coincubation of UC-112 with a known proteasome inhibitor Z-Leu-Leu-Leu-CHO (MG-132) rescued survivin inhibition, consistent with the anticipated mechanism of action for UC-112 [1]. in vivo: As a single agent, UC-112 strongly inhibits tumor growth and reduces both X chromosome-linked I
性状	Solid
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Wang J, et al. Discovery of novel second mitochondria-derived activator of caspase mimetics as selective inhibitor of apoptosis protein inhibitors. J Pharmacol Exp Ther. 2014 May;349(2):319-29. [2]. Qinghui Wang, et al. Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors. Eur J Med Chem

溶解度数据	In Vitro: DMSO : 33.33 mg/mL (95.65 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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