AEBSF hydrochloride|30827-99-7|(AEBSF盐酸盐)-陌孚医药/Medlife

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AEBSF hydrochloride (Synonyms: AEBSF盐酸盐)

目录号: PL02918 纯度: ≥99%

CAS No. :30827-99-7

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中文名称	AEBSF hydrochloride
中文别名	4-(2-氨乙基)苯磺酰氟盐酸盐;4-(2-氨乙基)苯磺酰氟盐酸盐[用于生化研究];4－(2-氨乙基)苯磺酰氟酸盐;4-(2-氨乙基)苯磺酰氟盐酸盐（AEBSF）;4-(2-氨乙基)苯磺酰氟盐酸盐,4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride;4－苯磺酰氟酸盐;AEBSF丝氨酸抑制剂;4-(2-氨乙基)苯磺;4-(2-氨乙基)苯磺酰氟盐酸盐;AEBSF盐酸盐
英文名称	AEBSF hydrochloride
英文别名	4-(2-Aminoethyl)benzene-1-sulfonyl fluoride hydrochloride;4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride;AEBSF hydrochloride;4-(2-Aminoethyl)benzenesulfonyl Fluoride Hydrochloride [for Biochemical Research];4-(2-AMINOETHYL)BENZENE- SULFONYL FLUORIDE;4-(2-AMINOETHYL)-BENZENESULFONYL FLUORIDE;4-(2-Aminoethyl)benzenesulfonyl fluoride, HCl;AEBSF;AEBSF (hydrochloride);Pefabloc® SC;4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride,AEBSF;Pefabloc SC
Cas No.	30827-99-7
分子式	C₈H₁₀NO₂FS^.HCl
分子量	239.69
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	AEBSF hydrochloride 是丝氨酸蛋白酶的不可逆抑制剂，可抑制例如胰凝乳蛋白酶，激肽释放酶，纤溶酶，凝血酶和胰蛋白酶。
生物活性	AEBSF hydrochloride is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.
性状	Solid
体外研究(In Vitro)	AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	AEBSF (76.8 mg/kg daily, i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection. AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Citron M, et al. Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF. Neuron. 1996 Jul;17(1):171-9 [2]. Nakabo Y, et al. Lysis of leukemic cells by human macrophages: inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor. J Leukoc Biol. 1996 Sep;60(3):328-36.

溶解度数据	In Vitro: DMSO : 100 mg/mL (417.21 mM; Need ultrasonic)H₂O : ≥ 100 mg/mL (417.21 mM)

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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