2,3-Dehydro-2-deoxy-N-acetylneuraminic acid|24967-27-9|(Neu5Ac2en; DANA)-陌孚医药/Medlife

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2,3-Dehydro-2-deoxy-N-acetylneuraminic acid (Synonyms: Neu5Ac2en; DANA)

目录号: PL02764 纯度: ≥99%

CAS No. :24967-27-9

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中文名称	2,3-Dehydro-2-deoxy-N-acetylneuraminic acid
中文别名	N-乙酰-2,3-二脱氢-2-脱氧神经氨酸;2,3-脱氢-2-脱氧-N-乙酰基神经氨酸;N-Acetyl-2,3-didehydro-2-deoxyneuraminic Acid N-乙酰-2,3-二脱氢-2-脱氧神经氨酸
英文名称	2,3-Dehydro-2-deoxy-N-acetylneuraminic acid
英文别名	D-glycero-D-galacto-Non-2-enonicacid, 5-(acetylamino)-2,6-anhydro-3,5-dideoxy-;N-Acetyl-2,3-didehydro-2-deoxyneuraminic Acid;1,3-Dehydro-2-Deoxy-N-Acetylneuraminic Acid;2,3-DEHYDRO-2-DEOXY-N-ACETYLNEURAMINIC ACID;N-ACETYLNEURAMINIC ACID, 2,3-DEHYDRO-2-DEOXY-, SODIUM SALT;2,3,4-TRIMETHYL-3-PENTANOL;2,3-Dehydro-2-deoxy-N-;2,3-Dehydro-2-deoxy-N-acetylneuraminic AcidDANA;2,3-didehydro-2-deoxy-N-acetylneuraminic acid;5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enoic acid;N-Acetyl-2,3-dehydro-2-deoxyneuraminic acid;DANA;Neu5Ac2en;2-Deoxy-2,3-dehydro-N-acetylneuraminic acid;2-deoxy-2,3-dehydro-n-acetyl-neuraminic acid;C11H17NO8;(2R,3R,4S)-3-acetamido-4-hydroxy-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid;5-acetamido-2,6-anhydro-3,5-dideoxy-;2,3-Dehydro-2-deoxy-N-acetylneuraminic acid;2,3-Dehydro-2-deoxy-N-acetylneuraminic Acid
Cas No.	24967-27-9
分子式	C₁₁H₁₇NO₈
分子量	291.25
包装储存	Powder -20°C 3 years；In solvent -80°C 6 months

产品详情

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) 是一种有效的神经氨酸酶 (neuraminidase) 抑制剂。N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid 对人 neuraminidase 酶具有抑制活性，对人 NEU1、NEU2、NEU3 和 NEU4 的 IC₅₀ 值分别为 143、43、61 和 74 μM。N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid 具有抗流感病毒活性。

生物活性

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC 50 s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity.

性状

Solid

体外研究(In Vitro)

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10-100 μM) signifcantly inhibits sialidase activity in INS-1D cells. has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10?mg/kg; i.p.; daily) attenuates pulmonary fibrosis in a mouse model. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Mice (M

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；In solvent -80°C 6 months

ClinicalTrial

参考文献

[1]. Magesh S, et al. Design, synthesis, and biological evaluation of human sialidase inhibitors. Part 1: selective inhibitors of lysosomal sialidase (NEU1). Bioorg Med Chem Lett. 2008;18(2):532-537.
[2]. Xiao A, et al. Sialidase-catalyzed one-pot multienzyme (OPME) synthesis of sialidase transition-state analogue inhibitors. ACS Catal. 2018;8(1):43-47.

溶解度数据	In Vitro: H₂O : 33.33 mg/mL (114.44 mM; Need ultrasonic)配制储备液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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