Tetragastrin|1947-37-1|(Cholecystokinin tetrapeptide; CCK-4)-陌孚医药/Medlife

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Tetragastrin (Synonyms: Cholecystokinin tetrapeptide; CCK-4)

目录号: PL02759 纯度: ≥99%

CAS No. :1947-37-1

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中文名称	Tetragastrin
中文别名	水合硫酸铀酰;四肽胃泌素
英文名称	Tetragastrin
英文别名	Gastrin Tetrapeptide;Gastrin Tetrapeptide, Cholecystokinin Tetrapeptide;TETRAGASTRIN;Cholecystokinin C-terminal tetrapeptide;cholecystokinin tetrapeptide;cholecystokinin-4;H-Trp-Met-Asp-Phe-NH2;L-Phenylalaninamide,L-tryptophyl-L-methionyl-L-a-aspartyl;CCK-4;Tetragastrin hydrochloride;Trp-Met-Asp-Phe amide;Cholecystokinin fragment 30-33 amide;CCK-4 Acetate;Cholecystokinin(36-39);H-Trp-Met-Asp-Phe-NH2 acetate;Cholecystokinin, CCK Tetrapeptide;4-7-Cholecystokinin-7 (swine) (9CI);CCK-4 Acetate, Gastrin Tetrapeptide;4-7-Cholecystokinin-7(swine) (9CI)
Cas No.	1947-37-1
分子式	C₂₉H₃₆N₆O₆S
分子量	596.70
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Tetragastrin (Cholecystokinin tetrapeptide; CCK-4) 是胃泌素的 C-末端四肽，能刺激胃液分泌。Tetragastrin 是一种胆囊收缩素 (CCK-4) 受体激动剂。Tetragastrin 具有胃黏膜保护。
生物活性	Tetragastrin (Cholecystokinin tetrapeptide; CCK-4) is the C-terminal tetrapeptide of gastrin. Tetragastrin can stimulate gastric secretion. Tetragastrin is a Cholecystokinin (CCK-4) receptor agonist. Gastric mucosal protection.
性状	Solid
体外研究(In Vitro)	The antagonist of histamine H2-receptors, Cimetidine inhibits the stimulatory effect of histamine in vitro and activates Tetragastrin stimulation of the adenylate cyclase activity. Tetragastrin and histamine activate adenylate cyclase of the rat gastric mucosa via different receptors. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	In inbred Wistar rats treated with N-methyl-N-nitro-N-nitrosoguanidine, Tetragastrin (s.c.; 1 mg/kg; every other day) treatment significantly reduces the incidence and the number of adenocarcinomas, and has a significantly lower labelling index of the antral mucosa. Tetragastrin has potential for enhancing gastric mucosal protection associated with mucus secretion and/or mucus synthesis on the surface mucosa of rat gastric mucosa. A significant increase in the mucin content was noted in the mucus gel and surface mucosal layer. An increase in mucin in the mucus gel and surface mucosa would thus appear due to the administration of Tetragastrin. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	WMDF-NH2
参考文献	[1]. M Tatsuta, et al. Effect of 6-hydroxydopamine on gastric carcinogenesis and tetragastrin inhibition of gastric carcinogenesis induced by N-methyl-N-nitro-N-nitrosoguanidine in Wistar rats. Cancer Res. 1989 Aug 1;49(15):4199-203. [2]. Nathalie Lara, et al. Pulmonary and systemic nitric oxide measurements during CCK-5-induced panic attacks. Neuropsychopharmacology. 2003 Oct;28(10):1840-5.

溶解度数据	In Vitro: DMSO : 8.33 mg/mL (13.96 mM; ultrasonic and warming and heat to 80°C)配制储备液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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