FGI-106 tetrahydrochloride|1149348-10-6|-陌孚医药/Medlife

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FGI-106 tetrahydrochloride

目录号: PL02686 纯度: ≥99%

CAS No. :1149348-10-6

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中文名称	FGI-106 tetrahydrochloride
英文名称	FGI-106 tetrahydrochloride
英文别名	76TVI971YY;Quino(8,7-H)quinoline-1,7-diamine, N1,N7-bis(3-(dimethylamino)propyl)-3,9-dimethyl-, hydrochloride (1:4);Q27266514;N,N'-Bis[3-(dimethylamino)propyl]-3,9-dimethylquinolino[8,7-h]quinoline-1,7-diamine tetrahydrochlori;FGI-106 tetrahydrochloride
Cas No.	1149348-10-6
分子式	C₂₈H₄₂Cl₄N₆
分子量	604.49
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	FGI-106 tetrahydrochloride 是一种有效的广谱抑制剂，对多种病毒具有抑制活性。FGI-106 tetrahydrochloride 具有抗埃博拉病毒 (EBOV)，裂谷病毒 (Rift Valley virus) 和登革热病毒 (Dengue Fever virus) 的活性，其 EC₅₀ 分别为 100 nM，800 nM 和 400-900 nM。FGI-106 tetrahydrochloride 还分别以 EC₅₀ 值为 200 nM 和 150 nM 抑制非失血性发热病毒 HCV 和 HIV-1。
生物活性	FGI-106 tetrahydrochloride is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 tetrahydrochloride is active against Ebola, Rift Valley and Dengue Fever viruses with EC 50 s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 tetrahydrochloride also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC 50 s of 200 nM and 150 nM, respectively.
性状	Solid
IC50 & Target[1][2]	EC50: 100 nM (Ebola virus), 800 nM (Rift Valley virus), 400-900 nM (Dengue Fever virus), 200 nM (HCV) and 150 nM (HIV-1)
体外研究(In Vitro)	Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC90 for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM. In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	FGI-106 (0.1-5 mg/kg; intraperitoneal injection; treatments on days 2 and 5; C57BL/6 or BALB/c mice) treatment decreases mortality from Zaire EBOV in a dose-dependent manner. has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Aman MJ, et al. Development of a broad-spectrum antiviral with activity against Ebola virus. Antiviral Res. 2009 Sep;83(3):245-51.

溶解度数据	In Vitro: DMSO : 6.67 mg/mL (11.03 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)配制储备液

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