INT-767|1000403-03-1|-陌孚医药/Medlife

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INT-767

目录号: PL02666 纯度: ≥98%

CAS No. :1000403-03-1

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中文名称	INT-767
中文别名	INT-767
英文名称	INT-767
英文别名	INT-767;Sodium;[(3R)-3-[(3R,5S,6R,7R,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,
Cas No.	1000403-03-1
分子式	C₂₅H₄₃NaO₆S
分子量	494.66
包装储存	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

产品详情	INT-767 是法尼醇 X 受体 (FXR)/TGR5双激动剂，EC₅₀ 值分别为 30 和 630 nM。
生物活性	INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC 50 s of 30 and 630 nM, respectively.
性状	Solid
体外研究(In Vitro)	INT-767 does not show cytotoxic effects in HepG2 cells, does not inhibit cytochrome P450 enzymes, is highly stable to phase I and II enzymatic modifications, and does not inhibit the human ether-a-go-go -related gene potassium channel. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	INT-767 (10-20 mg/kg; i.p.; daily for 2 weeks) decreases plasma total cholesterol and triglyceride levels in db/m and db/db mice . has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, sealed storage, away from moistur In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. Baghdasaryan A, et al. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mousecholangiopathy model by promoting biliary HCO3- output. Hepatology. 2011 Oct;54(4):1303-1312. [2]. Rizzo G, et al. Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor andTGR5 agonist. Mol Pharmacol. 2010 Oct;78(4):617-630.

溶解度数据	In Vitro: DMSO : ≥ 100 mg/mL (202.16 mM)H₂O : 100 mg/mL (202.16 mM; Need ultrasonic)

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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